Oxytocin for Hemorrhage Prevention During D&E

This study is looking at whether oxytocin can help prevent heavy bleeding (hemorrhage) during a second-trimester dilation and evacuation (D&E) procedure. You would receive either oxytocin mixed with normal saline, or normal saline alone, through an IV. Researchers will compare these two groups to see if oxytocin reduces the amount of blood loss and the rate of hemorrhage on the day of the procedure. This study is for women aged 18 to 55 who are having a D&E at 18 weeks or more of pregnancy and can speak English or Spanish. You cannot join if you refuse an IV, have certain blood clotting issues, or other specific medical conditions. The study is currently recruiting 150 participants.

Study design
This is an interventional study comparing two groups: one receiving oxytocin and one receiving normal saline. It plans to enroll 150 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Hemorrhage and quantitative blood loss are measured on the day of the procedure.

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NCT06141447

Changes in Hemorrhage With Prophylactic Oxytocin for Dilation and Evacuation

Recruiting
PHASE2Ages 18–55InterventionalPrevention
University of Colorado, Denver
~150 participants
Updated 2024-12-10 on ClinicalTrials.gov
What's tested:Oxytocin + normal salineNormal saline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hemorrhage
Measured over day of procedure
+1 more outcome measured
Hemorrhage
1 sites across 1 states
Colorado1

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Eligibility criteria

Inclusion

clinic-based D\&E at 18 weeks gestational age and above
speaks English or Spanish

Exclusion

refuses IV
history of coagulopathy
anticoagulant use in the preceding five days
chorioamnionitis or sepsis
suspected placenta accreta spectrum
intrauterine fetal demise
multiple gestation
use of misoprostol for cervical preparation
  • Hemorrhageday of procedure

    Quantitative blood loss greater than or equal to 500 mL or a clinical response to excessive bleeding such as transfusion or hospital admission

  • Quantitative blood lossday of procedure

    Measured blood loss during procedure