Omnipod 5 System Registry for Type 1 Diabetes

This study is a registry (a type of observational study) looking at how the Omnipod 5 System works in real life for children and adults with Type 1 Diabetes. The Omnipod 5 System is a tubeless insulin pump that works with the Dexcom G6 Continuous Glucose Monitoring System to automatically deliver insulin. Researchers want to see how safe and effective the Omnipod 5 System is. They will track important health measures like severe hypoglycemia (very low blood sugar), DKA (diabetic ketoacidosis, a serious complication), and A1c (a measure of average blood sugar over time) for up to 12 months. You can join if you have Type 1 Diabetes, are at least 2 years old, and are either starting the Omnipod 5 System soon or have been using it for less than two weeks. You also need to use specific types of U-100 insulin (Humalog U-100, Novolog, or Admelog). The study aims to enroll 2,200 participants.

Study design
This is an observational registry study involving 2,200 participants with Type 1 Diabetes. It is not a randomized trial and does not have a specified phase.
What's involved
You would be followed for 12 months. The study collects real-world information about your use of the Omnipod 5 System.
Compensation
Not stated in the trial record.
Follow-up
Participants are expected to be followed for 12 months after starting the study.

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NCT06144554

Post Market Registry for the Omnipod 5 System in Children and Adults With Type 1 Diabetes

Recruiting
Not specifiedAges 2+Observational
Insulet Corporation
~2,200 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Omnipod 5

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence rate of severe hypoglycemia
Measured over From baseline to study completion, up to 12 months.
+22 more outcomes measured
Type 1 Diabetes
1 sites across 1 states
New York1

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  • Incidence rate of severe hypoglycemiaFrom baseline to study completion, up to 12 months.

    Measures frequency of severe hypoglycemia

  • Incidence rate of DKAFrom baseline to study completion, up to 12 months.

    Measures frequency of DKA

  • A1c at 3, 6, 9 and 12 monthsComparing the change in A1c at baseline compared to at 3, 6, 9 and 12 months

    Measures device effectiveness

  • Percentage of time < 54 mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study continuous glucose monitoring system

  • Percentage of time < 70 mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study continuous glucose monitoring system

  • Percentage of time > 180 mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study continuous glucose monitoring system

  • Percentage of time > 250 mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study continuous glucose monitoring system

  • Percentage of time in range 70-180 mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study continuous glucose monitoring system

  • Mean Glucose mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study continuous glucose monitoring system

  • Standard deviation of glucose mg/dLFrom baseline to study completion, about 12 months

    measure of the range of glucose readings

  • Glucose management indicator %From baseline to study completion, up to 12 months

    MI tells you what your approximate A1C level is likely to be, based on the average glucose level from your CGM readings for 14 or more days.

  • Percentage of participants achieving A1C < 7%From baseline to study completion, up to 12 months

    measurement of percentage of participants with A1c less than 7%

  • Percentage of participants with time in range > 70%From baseline to study completion, up to12 months

    measurement of percentage of participants with time in range \> 70%

  • Percentage of participants with time below range (<70mg/dL) of < 4%From baseline to study completion, up to 12 months

    measurement of percentage of participants with time below range (\<70mg/dL) of \< 4%

  • Insulin UsageFrom baseline to study completion, up to 12 months

    Measure of insulin requirements

  • Body Mass Index (BMI) or BMI z-scoreat 6 months and at the end of registry participation, up to 12 months.

    Changes in body mass index

  • EQ-5D (inclusive of the Visual Analogue Scale (VAS))at baseline, at 6 months and at the end of registry participation, up to 12 months.

    Questionaire

  • Insulin Delivery Systems: Perceptions, Ideas, Reflections, and Expectations (INSPIRE)at baseline, at 6 months and at the end of registry participation, up to 12 months

    Questionaire

  • System Usability Scale (SUS)at baseline, at 6 months and at the end of registry participation, up to 12 months

    Questionnaire

  • Incidence rate of prolonged hyperglycemia (events per person months) during usage of Activity FeatureFrom baseline to study completion, up to 12 months

    Measuring rate of prolonged high sugar while in activity feature

  • Incidence rate of prolonged hyperglycemia (events per person months)From baseline to study completion, up to 12 months

    Measuring the occurrence of prolonged hyperglycemia

  • Incidence rate of prolonged hyperglycemia (events per person months) during usage of a Target Glucose of 140 mg/dL or 150 mg/dLFrom baseline to study completion, up to 12 months

    Measuring the occurrence of prolonged hyperglycemia while at a set target glucose of 140mg/dL or 150mg/dL

  • Glucose Outcomes during the 4-hour post-bolus period using the SmartBolus Calculator: o Percentage of time < 54 mg/dL o Percentage of time in range 70-180 mg/dLFrom baseline to study completion, up to 12 months

    Glucose metric from study CGM