Bupivacaine Dosing for Labor Pain Relief

This study is looking at the best dose of bupivacaine (a pain-relieving medication) to provide comfort during labor. You might be able to join if you are pregnant, between 37 and 42 weeks, have no major health problems, are less than 5 cm dilated, and want an epidural for labor pain with a pain score of 5 or higher. The researchers want to find the dose of bupivacaine that makes 90% of patients feel comfortable (pain score less than 3) within 30 minutes after receiving the medication. The study status is currently unclear, and they plan to enroll 120 participants.

Study design
This is an interventional study that will randomly assign participants to one of two epidural techniques (DPE or EPL). The dose of bupivacaine will be adjusted for each participant based on how the previous participant responded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain level will be measured 30 minutes after receiving the medication.

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NCT06146842

ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL

Recruiting
PHASE4All AgesInterventionalTreatment
Brigham and Women's Hospital
~120 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:Bupivacaine Hydrochloride

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
NRS <3 at 30 min
Measured over 30 minutes after time 0.
Labor Pain
1 sites across 1 states
Massachusetts1

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  • NRS <3 at 30 min30 minutes after time 0.

    Adequate analgesia is defined as NRS score less than 3 at 30 minutes after time 0.