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Acceptance-Based Healthy Lifestyle Intervention for Adolescent Girls with Overweight/Obesity

This study is looking into two different approaches to help adolescent girls (ages 14-19) who are overweight or have obesity. One approach is called Acceptance-based Treatment (ABT), which uses coaching and skill-building to promote healthy lifestyle changes. The other is Health Education, which provides information and resources. Researchers want to see if ABT leads to more weight loss and better overall health compared to health education. To join, you must be a girl between 14 and 19 years old and have a BMI (Body Mass Index) at or above the 85th percentile for your age and sex. The main goal is to measure changes in BMI z-score (a measure of body weight relative to height and age) after 6 months.

Study design
This interventional study plans to enroll 148 participants. It compares two behavioral interventions: Acceptance-based Treatment and Health Education.
What's involved
You would engage in treatment for 6 months, which includes a mix of in-person and remote group sessions. You would also complete various assessments.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, BMI z-score change, is measured at Month 6, indicating a follow-up period of at least 6 months.

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NCT06147973

An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents

Recruiting
NAAges 14–19InterventionalTreatment
Nemours Children's Clinic
~148 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Acceptance-based Treatment (ABT)Health Education (HE) Comparison

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
BMI z-score change
Measured over Month 6

Conditions

Overweight and Obesity

Explore related trials

ObesityOverweight

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Stephanie Manasse, PhD · PRINCIPAL_INVESTIGATOR · Drexel University

Who to contact

Stephanie Manasse, PhD
[email protected]
215-553-7157
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Ages 14-19
Gender identification as girl
BMI percentile ≥ 85th percentile for sex-and-age

Exclusion

Experience of weight loss of ≥5% of body weight in the past 6 months for any reason except post-partum weight loss
Having recently begun or changed the dosage of any medication known to affect appetite or body composition within the last 3 months
Plans to move out of the area within the next year
Active cancer or cancer requiring treatment in the past 2 years (except non-melanoma skin cancer)
Active or chronic infections (e.g., HIV or TB)
Active cardiovascular disease or event including hospitalization or therapeutic procedures for treatment of heart disease in the past 6 months
Active kidney disease
History of bariatric surgery
Lung disease: chronic obstructive airway disease requiring use of oxygen (e.g., emphysema or chronic bronchitis)
Diagnosed diabetes (type 1 or 2)
Any condition prohibiting physical activity
Diagnosis of an eating disorder
Have a mental handicap or are currently experiencing other severe psychopathology that would limit their ability to engage in the treatment program (e.g., severe depression, active psychotic disorder)
Recent or ongoing problem with drug abuse, alcohol abuse, or addiction
Currently pregnant or less than 3 months post-partum
Anticipation of a possible pregnancy in the next year
Unwillingness to report possible or confirmed pregnancies promptly during the course of the trial

What this trial measures

  • BMI z-score changeMonth 6

    Compare ABT vs. HE on BMI z-score change at post-treatment (month 6). The investigators hypothesize a significantly greater decrease in BMI z-scores in the ABT relative to HE.