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Regenerative Treatment for Peri-implantitis

This study is looking at a surgical treatment for peri-implantitis (gum disease around dental implants). Researchers want to compare a new type of membrane called reinforced PTFE Mesh (RPM) with a traditional collagen membrane. Both membranes are used with bone grafting to help regrow bone around the implant. The goal is to see which membrane works better at improving probing depth (a measure of gum health) and bone measurements around the implant. You might be able to join if you are at least 18 years old, generally healthy or have well-controlled health conditions, and have at least one dental implant with peri-implantitis. The study's current status is unclear.

Study design
This is a randomized controlled clinical trial involving 32 participants. Participants will be randomly assigned to receive treatment with either a collagen membrane or an RPM membrane.
What's involved
The diseased dental implant will be cleaned, and the bone defect will be filled with bone graft and covered by a membrane. Probing depth will be measured about 5 weeks before surgery and 8.5 months after, while bone measurements will be taken at the start and 8 months after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will have probing depth measured 8.5 months after surgery and bone measurements taken 8 months after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06153212

Regenerative Treatment of Peri-implantitis

Enrolling by Invitation
NAAges 18+InterventionalTreatment
University of Michigan
~32 participants
Updated 2026-07-02 on ClinicalTrials.gov
What's tested:Membrane placement with bone grafting

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Probing depth measurements in millimeters
Measured over About 5 weeks before baseline surgery and at 8.5 months after baseline surgery.
+1 more outcome measured

Conditions

Peri-Implantitis

Explore related trials

Dental peri-implantitis

Where it's being run

1 sites across 1 states
Michigan1

Study leadership

  • Muhammad Saleh, BDS, MSD · PRINCIPAL_INVESTIGATOR · University of Michigan

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥ 18 years
Physical status according to the American Society of Anesthesiology (ASA) I or II, which include patients who are systematically healthy or may suffer from mild to moderate, however well-controlled systemic diseases.
Subjects having at least one dental implant with peri-implantitis according to the definition proposed by the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Berglundh et al., 2018):
Full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth)
Correct 3-dimensional implant positioning, or buccal position ≤ 1 mm
Implants which have been in function for at least 6 months

Exclusion

A clearly mal-positioned dental implant
Significant interproximal horizontal bone loss (more than 50% of implant fixture length)
A mobile dental implant
Presence of uncontrolled or untreated periodontal disease
More than 2 weeks usage of antibiotics in the past two months
Subjects taking medications known to modify bone metabolism or those that can interfere with the normal wound healing (such as bisphosphonates, corticosteroids, hormone replacement therapy, parathyroid hormone, denosumab, strontium ranelate, etc.), or those with uncontrolled systemic diseases or conditions that may similarly affect the patient's healing (osteoporosis, osteopenia, hyperparathyroidism, Paget's disease, uncontrolled diabetes (HBA1c \> 8)).
Pregnant subjects or individuals attempting to get pregnant (self-reported)
Subjects smoking more than 10 cigarettes a day, or those with a history of drug or alcohol abuse (self-reported)
Subjects unable to maintain adequate oral hygiene (O'Leary plaque index more than 50%) (O'Leary et al., 1972)
Any other contraindications for undergoing periodontal surgery

What this trial measures

  • Probing depth measurements in millimetersAbout 5 weeks before baseline surgery and at 8.5 months after baseline surgery.

    To compare probing depth measurements using a periodontal probe after peri-implantitis treatment

  • Bone measurements in millimetersBaseline and 8 months after baseline surgery

    Bone measurements obtained from CBCT