Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B

{ "Imdusiran (AB-729) for Chronic Hepatitis B", "This study is looking at how a drug called Imdusiran (AB-729) works in the liver of people with chronic hepatitis B. Researchers want to understand how much of the drug gets into the liver and how it affects the hepatitis B virus. You would receive four injections of Imdusiran, one every 8 weeks. You would also have two liver biopsies (small tissue samples taken from your liver): one when you get your first dose of Imdusiran, and another 8 weeks after your last dose. This study is for adults over 18 who are in good general health. Up to 10 people will participate in this study, which is currently recruiting.", "design": "This is a small, single-center study that is not randomized. It will include up to 10 adult participants.", "commitments": "You would receive 4 injections of Imdusiran over 24 weeks. You would also undergo 2 liver biopsies, with an optional third biopsy at week 52.", "compensation": "Not stated in the trial record.", "follow_up": "The study measures drug levels in the liver 8 weeks after the last dose of Imdusiran, and there is an optional liver biopsy at week 52.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06154278

Intrahepatic and Peripheral Responses to Imdusiran (AB-729) in Chronic Hepatitis B

Recruiting
PHASE2Ages 18+InterventionalBasic science
University of Maryland, Baltimore
~10 participants
Updated 2025-09-11 on ClinicalTrials.gov
What's tested:Imdusiran (AB-729)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Intrahepatic concentration of Imdusiran (AB-729)
Measured over During intervention (with first dose of Imdusiran) and after intervention (8 weeks after last dose of Imdusiran)
Chronic Hepatitis B
1 sites across 1 states
Maryland1

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Eligibility criteria

Exclusion

If liver biopsy is available, the liver biopsy result supersedes (i) and (ii). 9. Subjects meeting any of the following laboratory parameters at screening:
  • Intrahepatic concentration of Imdusiran (AB-729)During intervention (with first dose of Imdusiran) and after intervention (8 weeks after last dose of Imdusiran)

    Intrahepatic drug concentration at day 0 (peak) and week 32 (trough)