mHealth App for Sleep in Opioid Use Disorder

This study is testing an mHealth (mobile health) app designed to improve sleep for people with Opioid Use Disorder (OUD) who are also receiving medication-assisted treatment (MAT) with buprenorphine. The app uses principles from cognitive behavioral therapy for insomnia (CBT-I) and other sleep interventions. You might be able to join if you are 18 or older, have been stable on buprenorphine for at least two weeks, and are experiencing significant sleep problems. The study aims to see if the app is practical and acceptable to participants, and if people stick with the program. We don't know the current recruitment status, but 40 people are planned to enroll.

Study design
This is a pilot randomized controlled trial with 40 participants. Participants will be randomly assigned to one of two groups: a full mHealth app or a simplified mHealth app with sleep hygiene instructions.
What's involved
You would download an mHealth app to your smartphone and complete the intervention within 6 weeks. You would also complete daily electronic sleep diaries for 6 weeks and weekly short assessments.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed at 6 weeks following enrollment.

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NCT06157840

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

Recruiting
NAAges 18+InterventionalTreatment
Medical University of South Carolina
~40 participants
Updated 2026-05-12 on ClinicalTrials.gov
What's tested:mHealth application and sleep health educationSimplified mHealth application and sleep health education

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Enrollment feasibility/acceptability benchmark of at least 30 persons completing entire study period - Enrollment and retention percentages
Measured over 6 weeks following enrollment
+2 more outcomes measured
Opioid Use Disorder
Poor Quality Sleep
1 sites across 1 states
South Carolina1
  • Allison K Wilkerson, Ph.D. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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Eligibility criteria

Inclusion

No experience of withdrawal symptoms in past 2 weeks
Being stabilized on buprenorphine
Currently experiencing clinically significant sleep disturbance (PSQI \> 5)
Able to read and understand English
Owns an Android or iOS smartphone
At least 18 years of age

Exclusion

Current psychotic symptoms
Current active suicidal ideation
Severe visual impairment
Current use of benzodiazepines
Current severe SUD other than OUD (i.e., \> 5 criteria met for any other SUD type per DSM-5)
Peripartum women
  • Enrollment feasibility/acceptability benchmark of at least 30 persons completing entire study period - Enrollment and retention percentages6 weeks following enrollment

    To achieve a minimum enrollment and retention percentage of 75% throughout the 6-week investigation period.

  • Protocol adherence feasibility/acceptability benchmarks of participants completing modules and sleep diaries each week - Engagement6 weeks following enrollment

    Completing at least one module per week, submitting a minimum of four sleep diaries per week, and implementing stimulus control and sleep restriction on at least 90% of nights.

  • mHealth App Usability Questionnaire6 weeks following enrollment

    Validated measure of mobile app usability with 3 sections: Ease of use/satisfaction, system information arrangement, and usefulness