The LION Study is testing Laquinimod eye drops to see how safe they are, how well people tolerate them, and how the drops spread in the eye. This study is for adults aged 18 or older who are scheduled for a pars plana vitrectomy (a type of eye surgery). Researchers will measure the concentration of Laquinimod in your eye fluid (aqueous humor and vitreous) and blood after two weeks of using the eye drops. The study aims to understand how Laquinimod works by looking at its effect on VEGF, a protein involved in inflammation. The study is currently recruiting 12 participants.

Study design

This is a single-center study with 12 participants. It starts with an open-label dose escalation, followed by a randomized comparison of two Laquinimod doses.

What's involved

You would use Laquinimod eye drops for two weeks. Samples of your eye fluid and blood will be taken after this period.

Compensation

Not stated in the trial record.

Follow-up

Your Laquinimod levels will be measured after two weeks of using the study drug.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.