Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

This study is looking at how hormones like insulin, glucagon, and somatostatin (which help control blood sugar) respond after people with cystic fibrosis (CF) drink Boost energy drink. The goal is to understand why some people with CF have trouble with their blood sugar. You might be able to join if you are 18 to 45 years old, have been diagnosed with CF, and are currently taking highly effective CFTR modulator therapy. You cannot join if you've had a transplant, have had recent lung problems, are pregnant, or have certain liver conditions. This study aims to find connections between these hormone responses and blood sugar issues in people with CF. The study plans to enroll 61 participants, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 61 participants.
What's involved
Participants will ingest 5 mL/kg of Boost energy drink. Blood samples will be taken to measure hormone levels for up to 3 hours.
Compensation
Not stated in the trial record.
Follow-up
Hormone levels will be measured for up to 3 hours after the mixed meal.

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NCT06163482

Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

Recruiting
Not specifiedAges 18–45Observational
University of Cincinnati
~61 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:Mixed meal

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Concentration of Insulin
Measured over Up to 3 hours
+3 more outcomes measured
Cystic Fibrosis
1 sites across 1 states
Ohio1
  • Jason Winnick, PhD · PRINCIPAL_INVESTIGATOR · University of Cincinnati

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Eligibility criteria

Inclusion

Diagnosed with cystic fibrosis
Aged 18 to 45 years
Males and females of any race and ethnicity
Receiving highly effective CFTR modular therapy

Exclusion

Transplant recipient
Acute lung function decline or exacerbation within the last 3 months
Use of systemic glucocorticoids
Pregnancy
Known liver disease that would be expected to significantly impact metabolic variable as interpreted by a study doctor
The presence of any other disease or condition, as interpreted by any one of the study doctors, that would be expected to confound the responses to liquid mixed meal or make participation in the study dangerous to the individual
People who are cognitively impaired
People who do not speak English
For CFRD patients, a daily insulin requirement that exceeds 0.8 U/kg/day
Any prior history of diabetic ketoacidosis.
  • Concentration of InsulinUp to 3 hours

    human plasma

  • Concentration of GlucagonUp to 3 hours

    human plasma

  • Concentration of SomatostatinUp to 3 hours

    human plasma

  • Concentration of GlucoseUp to 3 hours

    human plasma