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Observational Study of Neurologic Manifestations in Immune System Diseases

This observational study aims to better understand how immune system diseases affect the nervous system. Researchers want to learn more about the connection between these two systems and how immune problems can lead to neurological issues like problems with movement, thinking, or feeling. The study will look at people aged 2 and older who have known or suspected immune system diseases, as well as healthy relatives and volunteers. There are no specific interventions (treatments) being tested. The main goals are to describe the neurological symptoms in participants through exams and brain imaging, and to identify any genetic causes of their immune system problems. The study is currently unclear on its recruitment status and plans to enroll 350 participants.

Study design
This is an observational study, meaning no specific treatments are given. It plans to enroll 350 participants, including those with immune system diseases, healthy relatives, and healthy volunteers.
What's involved
You would undergo periodic clinical evaluations, including neurologic exams and potentially neuroimaging (like MRI). Biospecimens such as blood, urine, and saliva may be collected. Data and specimens from your routine medical care might also be used.
Compensation
Not stated in the trial record.
Follow-up
Your neurological symptoms and immune system characteristics will be measured through the end of your participation in the study.

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NCT06169150

Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity

Recruiting
Not specifiedAges 2+Observational
National Institute of Allergy and Infectious Diseases (NIAID)
~350 participants
Updated 2026-08-05 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Clinical characterization of neurologic manifestations in participants with recognized and unrecognized errors of immunity based on neurologic examination, neuroimaging, and other necessary neurologic tests depending on clinical presentation.
Measured over Through end of participation.
+1 more outcome measured

Conditions

Nervous System Disease
Immune System Disease

Explore related trials

Immune System DisorderInborn Error of ImmunityNervous System DisorderNeurodegenerationNeuroinfectionsNeuroinflammation

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Farinaz Safavi, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Allergy and Infectious Diseases (NIAID)

Who to contact

Kelsey L Yoo, P.A.-C
[email protected]
(240) 656-0596
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Decisionally impaired affected adult participants may have a legally authorized representative (LAR) to provide informed consent on their behalf.

What this trial measures

  • Clinical characterization of neurologic manifestations in participants with recognized and unrecognized errors of immunity based on neurologic examination, neuroimaging, and other necessary neurologic tests depending on clinical presentation.Through end of participation.

    Clinically characterize neurologic manifestations of errors of immunity via neurologic exam and neuroimaging.

  • Characterization of inherited or acquired errors of immunity in participants with rare neurologic diseases.Through end of participation.

    Determine genetic defects in participants.