DBS for Parkinson's Disease: Understanding Brain Signals
This study is exploring how Deep Brain Stimulation (DBS) works in people with Parkinson's disease. Researchers are testing different ways to deliver DBS, specifically targeting the subthalamic nucleus (STN) alone, the globus pallidus interna (GPi) alone, or a combination of both. The goal is to understand how DBS changes brain activity and to use these brain signals to guide where the DBS electrodes are placed during surgery and how they are programmed afterward. This could lead to more personalized and effective DBS treatment. You may be eligible if you are 18-89 years old, have advanced Parkinson's disease for at least 4 years, and are already planning to have awake DBS surgery. The study aims to validate brain signals during surgery and see if they can predict the best stimulation sites. The current recruitment status is unclear, with a planned enrollment of 36 participants.
- Study design
- This is an exploratory, single-center, double-blind, randomized crossover study involving 36 participants. It compares unilateral STN, GPi, and dual-target STN/GPi DBS for motor symptoms of Parkinson's disease.
- What's involved
- You would undergo standard DBS surgery, followed by battery placement approximately one week later. You would also have research clinical assessments at 4-month intervals after surgery and a final assessment at 16 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed with research clinical assessments at 4-month intervals after surgery, with a final assessment at 16 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
At a glance
Conditions
NCT06169852
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Alabama at Birmingham
Birmingham, Alabamastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Harrison Walker, MD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Validate the biological origin of brain signals using an external stimulation/recording system during standard of care Deep Brain Stimulation surgery, both awake and under general anesthesia.At standard of care DBS surgery (awake) and approximately one week later at standard of care battery placement (under general anesthesia).
The investigator will validate the biological origin of the signals using pairs of DBS pulses and neural refractoriness with an external stimulation/recording system at therapeutically relevant stimulus amplitudes (i.e., inside and outside the therapeutic window).
- Test whether directional DBS leads elicit spatiotemporally distinct oscillations in subthalamic nucleus versus globus pallidus interna.At standard of care DBS surgery (awake) and approximately one week later at standard of care battery placement (under general anesthesia).
This investigators efforts will yield granular spatial maps of neural engagement across the two canonical targets for PD to guide targeting (awake or under anesthesia) and clinical programming.
- Test whether spatial maps of DBS-evoked oscillations predict clinically effective stimulation sites on a directional DBS lead.At standard of care DBS surgery (awake), approximately one week later at standard of care battery placement (under general anesthesia), at in a research clinical assessment at 16 months after DBS surgery.
The investigator will test whether spatial maps of DBS-evoked neural activity predict clinically effective locations for directional DBS.