CORE-COMPARE Pilot Study for Coronary Heart Disease

This study is looking at how well a new, very detailed CT scan, called Aquilion Precision (Ultra-High Resolution CT or UHR CT), finds blockages in heart arteries compared to standard CT scans. We want to see if UHR CT is better at detecting coronary heart disease (CHD) in people who might have it. The study will compare the results of both types of CT scans to a procedure called catheterization, which is considered the most accurate way to find blockages. You might be able to join if you are between 21 and 85 years old, have symptoms that suggest CHD, and your heart doctor has recommended a CT scan of your heart arteries. The study is currently recruiting 140 participants.

Study design: This is an interventional study planning to enroll 140 participants. It compares Ultra-High Resolution CT with Conventional Computed Tomography.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: The primary outcome will be measured up to 24 months after the scan.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

CORE-COMPARE Pilot Study

Recruiting

NAAges 21–85Interventional

Johns Hopkins University

~140 participants

Updated 2026-04-13 on ClinicalTrials.gov

What's tested:Aquilion PrecisionConventional Computed Tomography

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

agreement between the number of patients with >70% stenosis detected by ultra-high-resolution tomography compared to conventional tomography, with catheterization considered as the gold standard.

Measured over Up to 24 Months

Conditions

Coronary Heart Disease (CHD)

NCT06170541

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

Johns Hopkins School of Medicine
Baltimore, Marylandstudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

Joao Lima, Professor · PRINCIPAL_INVESTIGATOR · MD

Who to contact

Joao Lima, Professor

[email protected]

4106141284

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

Patients aged 21-85 years

Clinical history suggestive of CHD who are referred by their primary cardiologist for further evaluation via Computed tomography angiography (CTA) will be asked to participate.

Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study CTA.

Ability to understand and willingness to sign the Informed Consent Form.

Exclusion

Known allergy to iodinated contrast media.

History of multiple myeloma or previous organ transplantation

Elevated serum creatinine (\> 1.5mg/dl) OR calculated creatinine clearance of \< 60 ml/min (using the Cockcroft-Gault formula

Atrial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)

Evidence of severe symptomatic heart failure (NYHA Class III or IV);

Known or suspected moderate or severe aortic stenosis

History of prior percutaneous coronary intervention (PCI) in one or more vessel or history of coronary arterial bypass grafting (CABG)

Suspected acute coronary syndrome

Presence of any other history or condition that the investigator feels would be problematic

What this trial measures

agreement between the number of patients with >70% stenosis detected by ultra-high-resolution tomography compared to conventional tomography, with catheterization considered as the gold standard.Up to 24 Months
The ultra-high-resolution CT images (UHRCT) and the reconstructed conventional CT resolution images (CRCT) will be independently reviewed by two observers (with a 60-day washout period between both images). The stenoses will be classified according to the Society of Cardiovascular Computed Tomography (SCCT) classification system (\<25%, 25-49%, 50-69%, 70-99%, and occluded). Patients with stenosis greater than 70% will be flagged. The primary outcome will be assessed for patients that underwent a clinically indicated invasive angiography (ICA). To compare agreement between UHRCT and CRCT studies while using ICA as the gold-standard, a concordance meta-analysis will be employed. This involves evaluating the agreement measures from each study, standardizing the results, and then comparing the concordance results of the two studies with the third study, considered the gold standard.

Trialytics