This study is looking at a new way to help people with Amyotrophic Lateral Sclerosis (ALS) improve hand strength and function. It uses a treatment called Spinal Cord Associative Plasticity (SCAP), which involves gentle electrical stimulation over the brain and spinal cord. Researchers have already seen that this can temporarily strengthen nerve connections between the brain and hand muscles in people with ALS. This study will personalize the SCAP treatment and then compare it with or without hand exercises. You might be able to join if you are 18 to 80 years old, have a diagnosis of ALS, and have some weakness in your hand muscles. The study will measure improvements in hand muscle response and hand dexterity (skillful use of your hands) for up to 6 months.

Study design

This study plans to enroll 32 participants. It will compare two-week programs of paired brain-spinal stimulation with or without hand exercises after an initial 2-3 month period of optimizing the intervention for each individual.

What's involved

Participants will undergo an initial 2-3 month period to personalize the intervention, followed by two-week programs of paired brain-spinal stimulation, with or without hand exercises. Hand dexterity and muscle response will be measured for up to 6 months.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed through study completion, for up to 6 months, to measure primary outcomes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.