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Understanding Exposure Therapy for OCD

This study is looking at how Exposure therapy, a common treatment for Obsessive-Compulsive Disorder (OCD), works best. Researchers want to understand why some people get better with this therapy and others don't, to help improve treatment for everyone. You might be able to join if you are 18-65 years old, have an OCD diagnosis, are seeking exposure therapy at McLean Hospital OCD Institute or San Diego State University, and can complete study tasks in English. The main goal is to see how much your OCD symptoms improve after up to 12 weeks of exposure therapy, measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS). The study aims to enroll 400 participants.

Study design
This interventional study plans to enroll 400 adult participants with Obsessive-Compulsive Disorder.
What's involved
You will complete exposure therapy for up to 12 weeks, with coached sessions lasting about 50 minutes. You will also complete baseline clinical and demographic measures, and weekly symptom reports.
Compensation
Not stated in the trial record.
Follow-up
Your OCD symptoms will be measured at up to 12 weeks after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06173752

Mechanisms of Exposure Therapy for OCD

Recruiting
NAAges 18–65InterventionalBasic science
Mclean Hospital
~400 participants
Updated 2026-06-25 on ClinicalTrials.gov
What's tested:Exposure therapy

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Yale-Brown Obsessive Compulsive Scale (YBOCS)
Measured over Up to 12 weeks

Conditions

Obsessive-Compulsive Disorder

Explore related trials

Obsessive Compulsive Disorder

Where it's being run

2 sites across 2 states
California1
Massachusetts1

Study leadership

  • Jennie M Kuckertz, PhD · PRINCIPAL_INVESTIGATOR · Mclean Hospital

Who to contact

Jennie M Kuckertz, PhD
[email protected]
617-855-2962
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Between the ages of 18-65 years old
Seeking exposure treatment at McLean Hospital OCD Institute or San Diego State University
Have a diagnosis of OCD
Able to complete study measures and treatment procedures in English

Exclusion

Acute symptoms of psychosis
Active suicidality (plan, means, intent and/or suicide attempt in past 3 months)
Presence of co-occurring symptoms that warrant higher level of care (e.g., inpatient treatment)
Presence of any medical, psychiatric, or developmental condition that would prevent patients from completing assessments or exposure exercises (e.g., non-verbal autism spectrum disorder)

What this trial measures

  • Yale-Brown Obsessive Compulsive Scale (YBOCS)Up to 12 weeks

    The YBOCS is a 10 self-report measure of OCD severity.