PH Sensitive MRI Based Resections of Glioblastoma

This study is testing a new way to remove glioblastoma, a type of brain cancer, during surgery. It uses a special type of MRI called amine chemical exchange saturation transfer pH weighted MRI before surgery. This MRI helps doctors find areas of the tumor that are harder to see, including those that have spread beyond the main tumor. During surgery, this information will guide doctors to remove more of the tumor. The main goal is to see if this new surgical approach causes any serious side effects within two months. This study is looking for 18 participants who are at least 18 years old and have newly diagnosed or recurring glioblastoma.

Study design
This is a single-center, single-arm study, meaning all participants will receive the same intervention. It aims to enroll 18 participants.
What's involved
You would undergo standard pre-operative medical checks and MRIs, including a special CEST-EPI MRI. The study involves surgery to remove the tumor, guided by the special MRI.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for measuring side effects is at 2 months. Your total participation in the study will last two years.

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NCT06176066

PH Sensitive MRI Based Resections of Glioblastoma

Recruiting
PHASE1Ages 18+InterventionalTreatment
University of California, Los Angeles
~18 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:CEST PH MRI based resection of glioblastoma

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Resection limiting toxicities
Measured over 2 months
Glioblastoma
1 sites across 1 states
California1

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  • Resection limiting toxicities2 months

    Given the surgical nature of the trial, surgical AEs or RLTs will be pre-determined for monitoring. These will be compared to the standard of care protocols for surgery for glioblastoma. To qualify as a resection limiting toxicity, this must be diagnosed using imaging and/or laboratory analysis and must require intervention (IV antibiotics, repeat surgery). Surgical Events (see full protocol for full details) Infection, hemorrhage, seizure, cerebral edema, hydrocephalus, venous sinus thrombosis, ischemic infarct, unexpected significant qualifying (see full protocol for details) neurological deficit