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TransHealthGUIDE: Support for Gender-Diverse Young Adults

This study, called TransHealthGUIDE, is testing an interactive educational digital platform designed for transgender and gender-diverse (TGD) young adults aged 18-29 and their caregivers. The goal is to see if using this platform can improve the mental health of TGD young adults. You might be eligible if you are a TGD individual aged 18-29 or a caregiver of a TGD individual in this age range, and live in specific states like California, Oregon, or New York. The study aims to reduce suicidal thoughts and psychological distress. Participants will either get immediate access to the platform and usual care, or usual care with access to the platform after six months. The study plans to enroll 500 people.

Study design
This is a randomized controlled trial, meaning participants are assigned by chance to one of two groups. The study plans to enroll 500 participants.
What's involved
Participants will be followed for 12 months, with mental health assessments at baseline, 3, 6, and 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06177600

TransHealthGUIDE: Transforming Health for Gender-Diverse Young Adults

Recruiting
NAAges 18–29InterventionalSupportive care
Boston Children's Hospital
~500 participants
Updated 2025-08-20 on ClinicalTrials.gov
What's tested:Interactive educational digital platform for transgender and gender-diverse (TGD) young adults and caregivers

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Columbia Suicide Severity Rating Scale (C-SSRS)
Measured over Baseline, 3, 6, and 12 months
+1 more outcome measured

Conditions

Transgender Persons
Health Services for Transgender Persons
Gender Identity

Explore related trials

Agender IdentityTransgender Persons

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Rena Xu · PRINCIPAL_INVESTIGATOR · Boston Children's Hospital

Who to contact

Cassandra Program Manager
[email protected]
617-919-1369
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Gender diverse individuals aged 18-29 years residing in California, Oregon, Illinois, Maryland, District of Columbia, Vermont, Connecticut, Massachusetts, Michigan, New Jersey, or New York
Caregivers of gender diverse individuals aged 18-29 years residing in California, Oregon, Illinois, Maryland, District of Columbia, Vermont, Connecticut, Massachusetts, Michigan, New Jersey, or New York

Exclusion

Inability to speak, read, and write English
Lack of device with Internet access
Current residence in location other than California, Oregon, Illinois, Maryland, District of Columbia, Vermont, Connecticut, Massachusetts, Michigan, New Jersey, or New York

What this trial measures

  • Columbia Suicide Severity Rating Scale (C-SSRS)Baseline, 3, 6, and 12 months

    Measure of past 3-month suicidality. Presence or absence of past 3-month suicidal ideation and risk.

  • Patient Health Questionnaire-9 (PHQ-9)Baseline, 3, 6, and 12 months

    Measure of past 2-week depression. Score range is 0-27 (higher scores indicate greater degree of depressive symptoms in past 2 weeks). Score \>=10 clinically elevated depressive symptoms.