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EUS-guided Celiac Plexus Block for Chronic Pancreatitis Pain

This study is looking at whether a procedure called EUS-guided celiac plexus block can help reduce abdominal pain in people with chronic pancreatitis. During this procedure, a doctor uses an endoscope (a thin, flexible tube with a camera) and ultrasound to guide an injection of bupivacaine (a local anesthetic) and triamcinolone (a steroid) near the celiac plexus nerves in your abdomen. Some participants will receive this injection, while others will have a sham procedure where no injection is given. The study aims to enroll 94 participants and is currently unclear if it's recruiting. To join, you must be at least 18 years old, have had abdominal pain for at least 3 months with a pain score of 3 or higher, and have a diagnosis of chronic pancreatitis based on specific EUS findings. The main goal is to see if participants experience adequate pain relief after one month.

Study design
This is an interventional study comparing EUS-guided celiac plexus block to a sham procedure. It plans to enroll 94 participants.
What's involved
Participants will undergo either an EUS-guided celiac plexus block or a sham procedure.
Compensation
Not stated in the trial record.
Follow-up
Pain relief will be measured at 1 month after the procedure.

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NCT06178315

EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

Recruiting
NAAges 18+InterventionalTreatment
Orlando Health, Inc.
~94 participants
Updated 2023-12-21 on ClinicalTrials.gov
What's tested:EUS-guided celiac plexus blockSham procedure

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of adequate pain relief
Measured over 1 month

Conditions

Chronic Pancreatitis

Explore related trials

Chronic Pancreatitis

Where it's being run

1 sites across 1 states
Florida1

Who to contact

Charles Melbern Wilcox, MD
[email protected]
321-841-2431
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Eligibility criteria

Inclusion

Age ≥ 18 years
Abdominal pain of at least 3 months duration and a VAS score ≥ 3, with or without the use of narcotic analgesics.
Diagnosis of chronic pancreatitis on EUS examination, with ≥ 5 features on EUS.
No other cause of abdominal pain

Exclusion

Age \< 18 years.
History of prior EUS-CPB.
Use of anticoagulants that cannot be discontinued for the procedure.
Clinically significant allergy to bupivacaine or triamcinolone.
Unable to obtain consent for the procedure from either the patient or LAR.
Intrauterine pregnancy.

What this trial measures

  • Rate of adequate pain relief1 month

    Rate of adequate pain relief in patients with chronic pancreatitis undergoing endoscopic ultrasound-guided celiac plexus block or sham procedure. Adequate pain relief is defined as a 50% reduction in composite pain score from baseline, measured using the Brief Pain Inventory-Short Form, at 1 month post-intervention.