Sleep Extension for Overweight and Obesity

This study is looking at how increasing the amount of time you sleep might affect certain fats in your blood called ceramides, and how your body uses sugar (insulin sensitivity). You could join if you are between 18 and 45 years old, are overweight or have obesity, and usually sleep less than 6.5 hours per night. The study will compare people who try to sleep 2 hours more each night with people who receive general health information. Researchers will measure your total plasma ceramides and insulin sensitivity right after the intervention to see if more sleep makes a difference. The study aims to enroll 70 participants.

Study design
This is a randomized controlled trial, meaning participants will be randomly assigned to either the sleep extension group or a control group. Researchers and participants will not know which group they are in until after the initial phase.
What's involved
You will have an initial screening for sleep disorders and about one week of at-home monitoring. After that, you will be in either the sleep extension or control group for 8 weeks, with regular contact with the study team. You will also have overnight lab visits to measure ceramides and insulin sensitivity.
Compensation
Not stated in the trial record.
Follow-up
Measurements for the primary outcomes (total plasma ceramides and insulin sensitivity) are taken immediately after the 8-week intervention period.

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NCT06180837

Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

Recruiting
NAAges 18–45InterventionalPrevention
University of Utah
~70 participants
Updated 2026-08-05 on ClinicalTrials.gov
What's tested:Sleep Extension Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Plasma Ceramides
Measured over Immediately after the intervention
+1 more outcome measured
Lifestyle Factors
Overweight and Obesity
Insulin Sensitivity
Eating Habit
Sleep Hygiene
Type 2 Diabetes
Sleep
Sleep Deprivation
Insufficient Sleep Syndrome
1 sites across 1 states
Utah1

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  • Total Plasma CeramidesImmediately after the intervention

    Total plasma ceramides will be measured by assessing plasma ceramides by targeted metabolomics.

  • Insulin SensitivityImmediately after the intervention

    Insulin sensitivity will be measured by the glucose infusion rate per kg body weight during the hyperinsulinemic-euglycemic clamp.