Prunes for Bone Health in Postmenopausal Women

This study is looking at whether eating prunes, along with calcium and vitamin D supplements, can help prevent bone loss in women after menopause. Researchers want to find out if a small amount of prunes (30 grams daily) can make a difference in your bone mineral density (a measure of bone strength). You might be able to join if you are a postmenopausal woman with some bone loss, but not severe, and are not currently taking hormone replacement therapy or other bone-affecting medications. The study will measure changes in your bone mineral density over two years to see if the prune intervention is successful. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 200 postmenopausal women. Participants will be randomly assigned to one of two groups: one receiving prunes and one not.
What's involved
You would take daily supplements for 24 months. You would have blood samples, physical activity recalls, food records, and bone scans (DXA and pQCT) at the start, 12 months, and 24 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 24 months after starting the study interventions.

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NCT06184646

Elucidating the Minimal Effective Dose of Prunes for Bone Health in Postmenopausal Women

Recruiting
NAAll AgesInterventionalPrevention
San Diego State University
~200 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:Prune

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes from baseline in bone mineral density at 12 and 24 months
Measured over Baseline, 12 months, and 24 months
Bone Disease, Metabolic
1 sites across 1 states
California1
  • Shirin Hooshmand, PhD · PRINCIPAL_INVESTIGATOR · San Diego State University

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Eligibility criteria

Inclusion

Postmenopausal
BMD t-score is between 0.5 and 2 SD below the mean
Not on hormone replacement therapy (HRT) and/or other pharmacological agents known to affect bone for at least three months prior to initiation of the study

Exclusion

Women whose BMD t-score at any site falls below 2.5 SD of the mean
Subjects receiving endocrine (e.g., prednisone, other glucocorticoids) or neuroactive (e.g., dilantin, phenobarbital) drugs or any drugs known to influence bone and calcium metabolism
Subjects who smoke cigarettes or vape
Regular consumption of dried plum or prune juice
  • Changes from baseline in bone mineral density at 12 and 24 monthsBaseline, 12 months, and 24 months

    bone mineral density as assessed by dual energy x-ray absorptiometry