Observational Study on MicroRNAs for Obstructive Sleep Apnea

This study is looking for ways to better identify and manage obstructive sleep apnea (OSA), a common sleep disorder. Researchers are studying tiny molecules called microRNAs in your blood to see if they can act as "biomarkers" for OSA. Biomarkers are like signals that can help doctors find OSA, check if treatments like Positive Airway Pressure (PAP) are working, and even predict how your blood pressure might respond to treatment. You could join if you are 18-75 years old and either have moderate-to-severe OSA and are willing to use PAP therapy, or if you do not have OSA. The study aims to see if microRNA levels change after 6 months of PAP treatment. The study is currently unclear on its recruitment status and plans to enroll 500 participants.

Study design
This is an observational study, meaning participants will be observed as part of their routine care. It aims to enroll 500 participants.
What's involved
If you have OSA, you would use Positive Airway Pressure (PAP) treatment as part of your routine clinical care. Blood samples will be taken at the start of the study and again after 6 months of PAP treatment, if applicable.
Compensation
Not stated in the trial record.
Follow-up
MicroRNA levels will be measured at the start of the study and after 6 months of PAP treatment, if applicable.

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NCT06189755

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

Recruiting
Not specifiedAges 18–75Observational
University of Pennsylvania
~500 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Positive Airway Pressure

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
microRNA
Measured over Once at baseline, and after 6 months of PAP treatment, if applicable
Obstructive Sleep Apnea
3 sites across 3 states
Ohio1
Pennsylvania1
Iceland1
  • Allan I Pack, MBChB, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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Eligibility criteria

Inclusion

age 18-75 years
moderate-severe OSA (defined as AHI ≥15 events/hour)
willing to accept PAP therapy
age 18-75 years
no OSA (defined as AHI \<5 events/hour)

Exclusion

current use of PAP or other OSA treatments
home oxygen therapy
recent changes (within 3 months) to BP medications among those who are on these medications
presence of Cheyne-Stokes Respiration (CSR) in sleep study
predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events)
pregnancy
clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
organ transplantation
self-reported sleep duration less than 5 hours per night on weeknights (work nights)
current night shift work
home oxygen therapy
pregnancy
clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant
organ transplantation
self-reported sleep duration less than 5 hours per night on weeknights (work nights)
current night shift work
  • microRNAOnce at baseline, and after 6 months of PAP treatment, if applicable

    Changes in circulating microRNA profile