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Observational Study on Contrast Echocardiography for Heart Failure and Pulmonary Vascular Disease

This study is looking at whether a non-invasive test called contrast echocardiography (an ultrasound of the heart using a special dye) can measure the amount of blood in your lungs (pulmonary blood volume, or PBV) as accurately as an invasive procedure called pulmonary artery wedge pressure (PAWP) during exercise. Researchers also want to see how PBV changes during exercise in people with and without heart failure and pulmonary vascular disease. You might be able to join if you are 18 or older, referred for an invasive exercise right heart catheterization to evaluate shortness of breath during activity, and have normal or low heart function, and any severity of pulmonary hypertension. The study aims to see if PBV measured at rest and during exercise can be a good indicator of how well your lungs are working. The current recruitment status is unclear.

Study design
This is an observational study planning to include 800 participants. It is not testing a new treatment, but rather observing and comparing existing diagnostic methods.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06195059

Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~800 participants
Updated 2026-08-20 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pulmonary Vascular Capacitance at Rest
Measured over Baseline
+1 more outcome measured

Conditions

Heart Failure
Pulmonary Vascular Disease

Explore related trials

Heart FailurePulmonary Vascular Disorder

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Barry Borlaug, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Circulatory Failure Research Team
507-255-2200
Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients referred to the cardiac catheterization laboratory for invasive exercise right heart catheterization for evaluating exertional dyspnea. Investigators will include patients with normal or low EF, and across the spectrum of pulmonary hypertension severity.

Exclusion

Patient inability or unwillingness to undergo echocardiography including a contrast method, or if echocardiography would, in the opinion of the investigator, somehow compromise the quality of data acquisition for the clinical case.
Prior adverse reaction to echo contrast administration

What this trial measures

  • Pulmonary Vascular Capacitance at RestBaseline

    Capacitance is defined as the total volume of blood in an organ or region at a given pressure. Pulmonary Vascular Capacitance (ml/mmHg) will be determined by pulmonary blood volume/mean pulmonary artery pressure as measured with high fidelity micromanometer catheters in the pulmonary vasculature at rest during the standard of care exercise hemodynamic assessment.

  • Pulmonary Vascular Capacitance During ExerciseBaseline

    Capacitance is defined as the total volume of blood in an organ or region at a given pressure. Pulmonary Vascular Capacitance (ml/mmHg) will be determined by pulmonary blood volume/mean pulmonary artery pressure as measured with high fidelity micromanometer catheters in the pulmonary vasculature during the exercise portion of the standard of care exercise hemodynamic assessment.