Psilocybin-Assisted Psychotherapy for Depression and Anxiety in Advanced Cancer

This study is looking into psilocybin-assisted psychotherapy for people with advanced cancer who are also experiencing depression and/or anxiety. You might be able to join if you are 25 or older, have certain types of advanced cancer (like non-small cell lung cancer or breast cancer), and are currently receiving maintenance therapy. The study will give participants either psilocybin or niacin by mouth. Researchers want to see if this treatment is safe and how well it helps with depression and anxiety. They also want to understand if at least 20% of eligible people join and if at least 60% of those who join complete the two treatment doses. The study is currently unclear on its recruitment status and plans to enroll 30 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 30 participants, but the specific phase of the study is not mentioned.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Safety and side effects will be measured through study completion, which is an average of 1 year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06200155

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

Recruiting
PHASE2Ages 25+InterventionalSupportive care
M.D. Anderson Cancer Center
~30 participants
Updated 2026-08-12 on ClinicalTrials.gov
What's tested:PsilocybinNiacin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Safety and adverse events (AEs)
Measured over Through study completion; an average of 1 year.
Depression, Anxiety
Psilocybin-Assisted Psychotherapy
Advanced Cancer
1 sites across 1 states
Texas1
  • Moran Amit, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

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  • Safety and adverse events (AEs)Through study completion; an average of 1 year.

    Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0