Olanzapine for Opioid Craving and Misuse in Cancer Pain
This study is testing whether a medication called olanzapine can help reduce opioid craving and misuse in people who are taking opioids for cancer pain. Olanzapine is a drug already used for other conditions. You might be able to join if you are 18 or older, have cancer pain, are currently taking opioids, and show signs of opioid misuse. The main goal is to see if olanzapine helps lower opioid craving. Researchers will also look at how it affects opioid misuse, the amount of opioids used, pain levels, and overall symptoms. The study aims to enroll 87 participants.
- Study design
- This is a double-blind, randomized control trial, meaning some participants will receive olanzapine and others a placebo (an inactive substance), and neither you nor your doctor will know which you are receiving. The study plans to include 87 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your safety and any side effects will be monitored throughout the study, which is expected to last an average of 1 year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Joseph Arthur, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Safety and adverse events (AEsThrough study completion; an average of 1 year
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0