Understanding Pain After Kidney Transplant

This observational study is looking at how the gut microbiome (the community of tiny living things in your intestines) and substances in your blood might be linked to pain in people who have received a kidney transplant. Researchers want to understand why nearly half of kidney transplant recipients experience ongoing pain. You could be eligible if you are 18 or older, receiving a kidney transplant at UI Health, and can provide informed consent. The study will measure your pain levels at the start, and then again at 3 and 6 months. This research aims to identify specific gut bacteria or blood markers that might explain why some people have more pain after a kidney transplant.

Study design
This is an observational study, meaning there are no interventions or treatments given. It plans to include 133 participants.
What's involved
You would have your pain levels measured at the beginning of the study, and then again at 3 months and 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after the start of the study.

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NCT06206486

The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation

Recruiting
Not specifiedAges 18+Observational
University of Illinois at Chicago
~133 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:no intervention, observational

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PROMIS
Measured over baseline, 3 months, 6 months (T scores range form 0-100, higher scores indicate worse level of symptoms).
Kidney Transplant Symptoms
Gut Microbiome
1 sites across 1 states
Illinois1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Receiving a kidney transplant at the University of Illinois Hospital \& Health Sciences System (UI Health) Transplant Center at the University of Illinois Chicago (UIC),
Planning to receive a kidney transplant at the UI Health Transplant Center
18 years of age or older (adult), and
Understand the study process and provide written informed consent to participate.

Exclusion

Having a history of colon cancer or an inflammatory bowel disease
Planning to receive a multiorgan transplant (e.g., simultaneous pancreas and kidney transplant).
Having a history of Clostridium difficile infection in the preceding 8 weeks.
  • PROMISbaseline, 3 months, 6 months (T scores range form 0-100, higher scores indicate worse level of symptoms).

    Patient Reported Outcomes Measurement System