DHA Supplementation for Growth-Restricted Preterm Infants

This study is looking at whether giving DHA (docosahexaenoic acid), a type of healthy fat, early to very preterm infants (babies born very early) who are also growth-restricted (smaller than expected for their age) can help them grow better. These babies often have low levels of DHA and fat, which can affect their growth. Researchers want to see if early DHA supplementation can lead to a bigger head circumference (a measure of head growth) without affecting how much fat they gain. To join, infants must be between 24 and 72 hours old, born between 22 and 32 weeks of pregnancy, and have a birth weight less than the 25th percentile. The main goal is to measure head circumference when the baby reaches 36 weeks postmenstrual age (their age from the start of the mother's last period) or when they are discharged from the hospital. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 152 participants. It is a randomized clinical trial, meaning participants will be assigned by chance to receive either DHA supplementation or standard care.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed until they reach 36 weeks postmenstrual age or are discharged from the hospital.

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NCT06207071

Early DHA/ARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial

Recruiting
NAAges 24–72InterventionalPrevention
University of Alabama at Birmingham
~152 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:DHA

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Head circumference at 36 weeks postmenstrual age or discharge
Measured over Birth to 36 weeks postmenstrual age or discharge
Infant Malnutrition
Light-For-Dates With Signs of Fetal Malnutrition
Premature
Nutrition Disorder, Infant
1 sites across 1 states
Alabama1

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Eligibility criteria

Inclusion

Gestational ages between 22 0/7 - 32 6/7 weeks gestation
\< 25th centile birthweight

Exclusion

Major congenital/chromosomal anomalies
Terminal illness in which decisions to withhold or limit support have been made
  • Head circumference at 36 weeks postmenstrual age or dischargeBirth to 36 weeks postmenstrual age or discharge

    Declines in head circumference z scores from birth to 36 weeks postmenstrual age