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Observational Study for Thyroid Nodule Identification

This study is looking at new ways to identify and tell the difference between thyroid nodules (lumps in the thyroid gland) using special imaging techniques. Researchers want to see how well methods like vibro-acoustography (VA), Shear Wave Ultrasound Vibrometry (SDUV), and Comb Push shear elastography (CUSE) can detect and classify these nodules as either cancerous (malignant) or non-cancerous (benign). They will compare these new methods to standard ultrasound. You might be able to join if you are at least 8 years old and your doctor suspects you have thyroid cancer, or if you are 18 or older and have been treated for thyroid cancer before. The study aims to enroll 650 participants.

Study design
This is an observational study, meaning researchers will collect information without giving you a specific treatment. It will involve 650 participants.
What's involved
You would undergo ultrasound imaging as part of this study. The record does not specify the number of visits or other procedures.
Compensation
Not stated in the trial record.
Follow-up
Researchers will collect information at baseline, and then at 3, 6, and 12 months after any ablation treatment you may receive as part of your regular care.

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NCT06207188

Identification and Differentiation of Thyroid Nodules by Acoustic Imaging and Viscoelastic Parameters

Recruiting
Not specifiedAges 8+Observational
Mayo Clinic
~650 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of nodules successfully sited by vibro-acoustography (VA)
Measured over Baseline, 3 months post ablation, 6 months post ablation, 12 months post ablation
+1 more outcome measured

Conditions

Thyroid Gland Carcinoma

Explore related trials

Thyroid Gland Carcinoma

Where it's being run

3 sites across 3 states
Arizona1
Florida1
Minnesota1

Study leadership

  • Azra Alizad, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic in Rochester

Who to contact

Clinical Trials Referral Office
[email protected]
855-776-0015
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

\* Male and female patient volunteers ages 8 and up who are suspicious for thyroid cancer
Patients who have palpable and sonographically detectable lymph nodes or nonthyroidal neck masses and are referred to Radiology Department or Endocrinology for fine-needle aspiration biopsy (FNAB)
Patients 18 and up who were previously diagnosed with thyroid cancer and treated with thyroidectomy and recently diagnosed as having recurrence nodes on thyroid bed or on their neck

Exclusion

Because thyroid cancer is rare under the age of 8 years, children younger than this age are excluded from the study
Having FNAB or surgical biopsy on thyroid in less than two weeks for thyroid nodule detection group
Having FNAB or surgical biopsy on cervical lymph nodes or non- thyroidal masses for this group of patients

What this trial measures

  • Incidence of nodules successfully sited by vibro-acoustography (VA)Baseline, 3 months post ablation, 6 months post ablation, 12 months post ablation

    Successful nodule localization will be assessed by the review of the VA image relative to the nodule location information from the reference ultrasound (US) image (agree/disagree on location will be determined for each nodule).

  • Specificity of VA in differentiating malignant and benign of thyroid nodulesBaseline, 3 months post ablation, 6 months post ablation, 12 months post ablation

    Specificity of VA in differentiating malignant and benign of thyroid nodules will be determined by comparing the VA image to the US image.