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DASH-Style Diet for Kidney Stone Disease

This study is looking at how a healthy diet might affect your risk of developing kidney stones. Researchers want to see if following a DASH-style diet (Dietary Approaches to Stop Hypertension) can improve factors in your urine that contribute to kidney stone formation. You could be eligible if you are between 19 and 89 years old, live in the Birmingham, AL area, and have a history of kidney stones. The study will compare the DASH-style diet to a Western-style diet, and all meals will be provided for one week. The main goal is to see the difference in calcium oxalate supersaturation (a measure of stone risk) between the two diet groups after this week.

Study design
This is an interventional study planning to enroll 48 participants. Participants will be randomly assigned to either a DASH-style diet or a Western-style diet.
What's involved
Participants will follow an assigned diet for one week, with all meals provided. You will also need to perform 24-hour urine collections.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at Days 6-7 of the assigned intervention, suggesting a short follow-up period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06210009

Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease

Recruiting
NAAges 19–89InterventionalPrevention
University of Alabama at Birmingham
~48 participants
Updated 2026-01-13 on ClinicalTrials.gov
What's tested:DASH-Style DietWestern-Style Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference between the two arms in supersaturation of calcium oxalate
Measured over Days 6-7 of the assigned intervention

Conditions

Kidney Stone

Explore related trials

Nephrolithiasis

Where it's being run

1 sites across 1 states
Alabama1

Who to contact

Joseph Crivelli, MD
[email protected]
205-996-8765
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Birmingham, AL area participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study OR patients of the University of Alabama at Birmingham/Kirklin Clinic
Self-reported, documented, and/or prior imaging-based diagnosis of kidney stone disease
Age 19-89
Any sex
Any race
Able to provide informed consent
Willing to perform 24-hour urine collections
Willing to consume meals prepared by Bionutrition Unit
No food allergies/intolerance to any of the foods in the study menus
Willing to stop for 7 days before and during study: Multivitamins and/or Dietary supplements (including calcium and vitamin C)

Exclusion

Dialysis
Kidney transplant recipient
Estimated glomerular filtration rate (eGFR) \<60 ml/min/1.73m2 based on historical laboratory measurements
Renal tubular acidosis
Current use of acetazolamide, topiramate, or zonisamide
Primary hyperparathyroidism or history of parathyroidectomy
Hyperthyroidism
Sarcoidosis
Primary hyperoxaluria
Cystinuria
Nephrotic syndrome
Malabsorptive conditions including inflammatory bowel disease or history of malabsorptive surgery (e.g., Roux-en-Y gastric bypass, small bowel resection)
Urinary retention requiring catheterization
Urinary diversion
Pregnancy
Breastfeeding
Malignancy treated in the past 12 months other than non-melanoma skin cancer

What this trial measures

  • Difference between the two arms in supersaturation of calcium oxalateDays 6-7 of the assigned intervention

    Supersaturation of calcium oxalate is an index reflecting the propensity for the formation and growth of the most common stone type (calcium oxalate), which is calculated using excretion rates including urinary volume, calcium, citrate, and oxalate.