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EXercise Cardiac Magnetic Resonance Assessment for Paroxysmal Atrial Fibrillation

This study is looking at how catheter ablation, a procedure to treat an irregular heartbeat, affects your heart's ability to pump blood during exercise if you have paroxysmal atrial fibrillation (AF), a type of irregular heartbeat. Researchers will observe changes in your heart's left upper chamber (left atrial) function and your overall exercise ability after the ablation. You may be able to join if you are at least 18 years old, have paroxysmal AF, and are scheduled for catheter ablation. The study aims to see how your heart's ability to store and release blood changes during exercise after the procedure. The study status is currently unclear.

Study design
This is an observational study planning to enroll 50 participants. It is not specified if there are different treatment groups.
What's involved
You will complete self-report evaluations, a cardiopulmonary exercise test (CPET), a transthoracic echocardiogram, and ambulatory cardiac rhythm assessment. These tests will be done at the beginning and again 5-6 months after your catheter ablation.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 5-6 months (150-180 days) after catheter ablation for follow-up testing.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06212791

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Recruiting
Not specifiedAges 18+Observational
Virginia Commonwealth University
~50 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:Self- Report Evaluation-Duke Activity Status IndexSelf- Report Evaluation Atrial Fibrillation Effect on Quality of Life QuestionnaireCardiopulmonary exercise test (CPET)Transthoracic echocardiogramAmbulatory cardiac rhythm assessmentCardiovascular magnetic resonance (CMR)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in LA reservoir function reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF.
Measured over Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.

Conditions

Paroxysmal Atrial Fibrillation

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Atrial Fibrillation

NCT06212791

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Virginia Commonwealth University

    Richmond, Virginiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Cory Trankle · PRINCIPAL_INVESTIGATOR · Virginia Commonwealth University

Who to contact

Pamela Grizzard
[email protected]
804-628-6234
Email the study team

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Eligibility criteria

Inclusion

Age ≥18 years
Diagnosis of paroxysmal AF
Left ventricular ejection fraction ≥50%
Scheduled for catheter ablation
Able to speak, hear, and read English
Willing and able to provide informed consent

Exclusion

Persistent or permanent AF
Prior ablation (catheter based or surgical) for AF
Significant sinus node dysfunction
Implanted pacemaker or defibrillator
Contraindication to or inability to complete cardiovascular magnetic resonance study
Contraindication to or inability to complete exercise testing
Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
Severe left ventricular hypertrophy
Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:
Hypertrophic cardiomyopathy
Cardiac amyloidosis
Constrictive pericarditis
Pulmonary arterial hypertension
Prior cardiac surgery
Active pregnancy

What this trial measures

  • Change in LA reservoir function reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF.Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.

    Change in LA reservoir volume reserve from baseline to follow up, change in left ventricular (LV) stroke volume reserve from baseline to follow up, correlation between changes in LA reservoir volume reserve and changes in LV stroke volume reserve. Therefore the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation.