Observational Study of Children with Hypochondroplasia
This is an observational study for children with Hypochondroplasia, a genetic condition affecting bone growth. The study aims to understand how children with Hypochondroplasia grow over time and how the condition progresses. Researchers will collect growth measurements and other health information. To join, your child must be 15 years old or younger and have a confirmed genetic diagnosis of Hypochondroplasia. Children with other genetic short stature conditions are not eligible. The study will look at changes in growth speed, height, and height compared to other children over a period of up to 15 years. The current recruitment status is unclear.
- Study design
- This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to enroll 400 participants.
- What's involved
- Participants will have growth measurements and other health information collected every 6 months for up to 15 years.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for up to 15 years, with measurements taken every 6 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Multicenter Multinational Observational Study of Children With Hypochondroplasia
At a glance
Conditions
NCT06212947
Where you'd take part
This study runs at 43 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Akron Children's Hospital
Akron, Ohiono site contact published
Not yet recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinoisno site contact published
Recruiting
Boston Children's Hospital
Boston, Massachusettsno site contact published
Recruiting
Cedars-Sinai Medical Center
Los Angeles, Californiano site contact published
Not yet recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canadano site contact published
Not yet recruiting
Children's National Health System
Washington D.C., District of Columbiano site contact published
Recruiting
CHU de Toulouse - Hopital des Efants
Toulouse, Franceno site contact published
Recruiting
Cook Children's Endocrinology
Fort Worth, Texasno site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Medical Director, MD · STUDY_DIRECTOR · BioMarin Pharmaceutical
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Change in annualized growth velocity (AGV)Every 6 months through end of study, up to 15 years
- Change in Height Z-scoreEvery 6 months through end of study, up to 15 years
- Change in HeightEvery 6 months through end of study, up to 15 years
- Change in BMIEvery 6 months through end of study, up to 15 years
- Change in BMI Z-scoreEvery 6 months through end of study, up to 15 years
- Change in ratios of upper to lower body segmentsEvery 6 months through end of study, up to 15 years
- Change in ratios of upper and lower leg length ratioEvery 6 months through end of study, up to 15 years
- Change in ratio of arms span to standing height ratioEvery 6 months through end of study, up to 15 years