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Spinal Cord Stimulation for Spinal Cord Injury Recovery

This study is exploring how two types of spinal cord stimulation, Transcutaneous Spinal Cord Stimulation (TSS) and Epidural Spinal Stimulation (ESS), can help people with spinal cord injuries regain movement and standing ability. Researchers want to understand how these devices work to improve recovery. You might be eligible if you are between 22 and 75 years old, can provide informed consent, and are willing to follow all study procedures. The main goal is to see if these interventions can improve the strength in your legs, which will be measured at different times over 16 weeks. The study plans to enroll 60 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 60 participants. It is designed to compare two different spinal cord stimulation methods.
What's involved
You would have assessments of your leg strength at the beginning of the study, after 6 weeks, after 11 weeks, and at a follow-up visit at 16 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your leg strength will be assessed at a follow-up visit 16 weeks after the study begins.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06213012

Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

Recruiting
NAAges 22–75InterventionalTreatment
The Methodist Hospital Research Institute
~60 participants
Updated 2026-03-30 on ClinicalTrials.gov
What's tested:Transcutaneous Spinal cord StimulationEpidural Spinal Stimulation (ESS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assessment of force generation by lower limbs
Measured over Baseline 1(week 1), baseline 2(week 6), post interventions (week 11), and follow up (week 16)

Conditions

Spinal Cord Injuries
Neuromodulation

Explore related trials

Spinal Cord Injury

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Dimitry Sayenko, MD, PhD · PRINCIPAL_INVESTIGATOR · The Methodist Hospital Research Institute

Who to contact

Jenny Dinh, BS
[email protected]
585-507-1706
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Personal or first-degree family history of seizures or epilepsy.
Metal in the head, except mouth implants.
History of suicide attempts.
History of intracranial lesions, increased intracranial pressure, or stroke.
Current use of tricyclic anti-depressants, selective serotonin reuptake inhibitors (SSRIs), serotonin nor-epinephrine reuptake inhibitors (SNRIs), buproprion (Wellbutrin), or tramadol.

What this trial measures

  • Assessment of force generation by lower limbsBaseline 1(week 1), baseline 2(week 6), post interventions (week 11), and follow up (week 16)

    Neuromotor outcomes will be assessed during supine and upright standing, focusing on leg extension force output. Measurements will be taken under various conditions, including voluntary effort without spinal stimulation, and in the presence of Transcutaneous Spinal Stimulation (TSS), Epidural Spinal Stimulation (ESS), or Sham stimulation. The force output will be quantified in newtons (N). The magnitude of EMG signals will be quantified and expressed in millivolts (mV).