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Healthy Diets with Plant Oils for Heart and Metabolic Health

This study is looking at how different healthy diets, specifically those containing cottonseed oil compared to other plant oils, affect your heart and metabolic health. Researchers want to see if a healthy diet with cottonseed oil improves your LDL-cholesterol (often called "bad" cholesterol) more than diets with other plant oils. You might be able to join if you are between 25 and 60 years old, have LDL-cholesterol between 100 and 190 mg/dL, and a BMI between 25 and 40 kg/m2. The study is currently unclear on its recruitment status and plans to enroll 52 participants. Success will be measured by changes in LDL-cholesterol after 4 weeks.

Study design
This is an interventional study that will enroll 52 participants. It is a randomized crossover study, meaning participants will try different diets in a random order.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, LDL-cholesterol, is measured at 4 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06216678

The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health

Recruiting
NAAges 25–60InterventionalPrevention
Penn State University
~52 participants
Updated 2026-02-02 on ClinicalTrials.gov
What's tested:Healthy Dietary Pattern with Cottonseed OilHealthy Dietary Pattern with Fatty Acid-Matched Plant OilsHealthy Dietary Pattern with PUFA:SFA Ratio-Matched Plant Oil

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
LDL-cholesterol concentration
Measured over 4 weeks

Conditions

Cardiovascular Diseases

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Cardiovascular Disorder

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Kristina Petersen, PhD
[email protected]
814-865-7206
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

LDL-C ≥100 mg/dL and ≤190 mg/dL
BMI of 25-40 kg/m2
Blood pressure \<140/90 mmHg
Fasting blood glucose \<126 mg/dL
Fasting triglycerides \<350 mg/dL
≤10% change in body weight for 6 months prior to enrollment

Exclusion

Type 1 or type 2 diabetes or fasting blood glucose ≥126 mg/dL
Prescription of anti-hypertensive, lipid lowering or glucose lowering drugs
Intake of supplements that affect the outcomes of interest and unwilling to cease during the study period
Diagnosed liver, kidney, or autoimmune disease
Prior cardiovascular event (e.g., stroke, heart attack)
Current pregnancy or intention of pregnancy within the next 6 months
Lactation within prior 6 months
Follows a vegetarian or vegan diet
Food allergies/intolerance/sensitives/dislikes of foods included in the study menu
Antibiotic use within the prior 1 month
Oral steroid use within the prior 1 month
Use of tobacco or nicotine containing products with in the past 6 months
Cancer any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer with in the past 5 years (eligible if ≥5 years without recurrence)
Participation in another clinical trial within 30 days of baseline
Currently following a restricted or weight loss diet
Prior bariatric surgery
Intake of \>14 alcoholic drinks/week and/or lack of willingness to consume a maximum of two standard drinks per week while enrolled in the study and/or not willing to avoid alcohol consumption for 48 hour prior to test visits

What this trial measures

  • LDL-cholesterol concentration4 weeks

    Assessed from fasting blood draw expressed in mg/dL. LDL-cholesterol will be measured directly via enzymatic assay. The mean of the LDL-cholesterol values from day 1 and day 2 testing will be used for analysis.