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The CAMERA Study: Heart and Metabolism in Healthy Adults

This study, called CAMERA, is looking at how your heart and metabolism work when you are healthy, both at rest and during exercise. Researchers will use procedures like Right Heart Catheterization (RHC), Magnetic Resonance Imaging (MRI), and DEXA scans to understand these processes. They are especially interested in your pulmonary capillary wedge pressure (PCWP), which is a measure of pressure in your heart. You can join if you are a healthy adult, aged 30 or older, without symptoms of breathlessness or fatigue, and have a left ventricular ejection fraction (EF) of 50% or higher. The study aims to understand these measurements in healthy people across different ages. The current recruitment status is unclear, and the study plans to enroll 80 participants.

Study design
This is an interventional study with a planned enrollment of 80 healthy adults. It is not specified if it is randomized or blinded.
What's involved
Participants will undergo procedures including Right Heart Catheterization (RHC), Magnetic Resonance Imaging (MRI), and DEXA scans. These procedures will assess heart function, structure, and body composition.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, pulmonary capillary wedge pressure (PCWP) at rest and during exercise, are measured at Baseline. Further follow-up duration is not specified.

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NCT06220396

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Recruiting
NAAges 30+InterventionalBasic science
Mayo Clinic
~80 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Right Heart Catheterization with Hemodynamics and Limited EchocardiogramMagnetic Resonance Imaging (MRI)Dual X-ray absorptiometry (DEXA) scan

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pulmonary Capillary Wedge Pressure (PCWP) at rest
Measured over Baseline
+1 more outcome measured

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Barry Borlaug, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Brendon Urena
[email protected]
507-538-8305
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
Informed consent were obtained.
No history of heart failure.
Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.

Exclusion

Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
Any diagnosis of heart failure
Symptomatic coronary artery disease (e.g., patients with chronic angina)
Symptomatic valvular heart disease
Pulmonary hypertension
Cardiomyopathies
High output heart failure
Pericardial disease
Clinically significant chronic lung disease in the opinion of the investigators
Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men)
Estimated glomerular filtration rate ≤30mL/min
Pregnant women
Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)

What this trial measures

  • Pulmonary Capillary Wedge Pressure (PCWP) at restBaseline

    Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter at rest.

  • Pulmonary Capillary Wedge Pressure (PCWP) during exerciseBaseline

    Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.