Reducing Chronic Hypertension After Preeclampsia

This study is looking at whether early and intensive blood pressure control after pregnancy can reduce the risk of developing long-term (chronic) high blood pressure and improve heart and blood vessel health. If you recently experienced a hypertensive disorder of pregnancy (like preeclampsia or gestational hypertension) and are within 4 days postpartum, you might be able to join. The study will compare two approaches: one group will receive the medication nifedipine ER (extended-release) if their blood pressure is 140/90 mmHg or higher, and the other group will receive nifedipine ER if their blood pressure is 150/100 mmHg or higher. The main goal is to see if the intensive blood pressure control group has a lower rate of stage I hypertension one year after delivery. The study is currently recruiting participants.

Study design
This is a multicenter randomized controlled trial involving 618 participants. Participants will be randomly assigned to either an intensive blood pressure control group or a usual care group.
What's involved
You would undergo blood pressure monitoring, cardiovascular function assessments, and biomarker collection at the start, at 6 weeks, and at 12 months postpartum.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year postpartum to assess the primary outcome.

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NCT06220721

Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

Recruiting
NAAges 18+InterventionalPrevention
Medical College of Wisconsin
~618 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Nifedipine ER

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Chronic hypertension
Measured over One year postpartum
Hypertension, Pregnancy-Induced
2 sites across 2 states
Illinois1
Wisconsin1
  • Anna Palatnik, MD · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Hypertensive disorders of pregnancy (HDP) diagnosis, specifically gestational hypertension, preeclampsia, eclampsia, or HELLP syndrome, according to ACOG guidelines
Postpartum day 0-4
Age ≥ 18 years
Able to communicate in English or in Spanish
Has an established OBGYN at an MCW or NU health system practice that has access to Epic electronic medical records.

Exclusion

Pre-gestational hypertension
Type 1 or type 2 diabetes mellitus
Admitted to intensive care unit at the time of screening
Diagnosed with HDP during postpartum readmission after discharge from delivery hospitalization
Getting discharged on the day of screening
Known allergy or contraindication to nifedipine ER
Inability or unwillingness to provide informed consent
Already taking long-acting antihypertensive medication for standard care
Maternal conditions that impact study outcomes: sickle cell disease, systemic lupus erythematosus
  • Chronic hypertensionOne year postpartum

    Diagnosis of chronic hypertension, defined as stage I hypertension with BP \>130/80 mmHg