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Comparing Fixed vs. Adjusted Meal Tests for Glucose Response

This study is comparing two ways of giving a special liquid meal called a Mixed Meal Tolerance Test (MMTT) to see how it affects blood sugar (glucose) levels. One way is a "Fixed Mixed Meal Test" where everyone gets a 900 calorie meal. The other is an "Adjusted Mixed Meal Test" where the meal size is based on your body weight. Researchers want to find out which method shows more differences in glucose levels among people with different body sizes. This information will help them choose the best way to do these tests in future research. You can join if you are a healthy adult, aged 18 or older. The study is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll 79 healthy volunteers. It compares two different meal dosing methods.
What's involved
You will have 3 or 4 clinic visits, each lasting up to 8 hours, over an 8-week period. These visits will include baseline measurements like height, weight, and waist size.
Compensation
Not stated in the trial record.
Follow-up
Your glucose response will be measured at Baseline and at Visit 3/4.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06223555

Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose

Recruiting
NAAges 18–99InterventionalBasic science
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~79 participants
Updated 2026-08-18 on ClinicalTrials.gov
What's tested:Fixed Mixed Meal TestAdjusted Mixed Meal Test

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To determine whether an adjusted energy dose MMTTor a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs.
Measured over Baseline, Visit 3/4

Conditions

Obesity
Healthy Volunteer

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Healthy Volunteer

Where it's being run

1 sites across 1 states
Arizona1

Study leadership

  • Susanne M Votruba, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who to contact

Susanne M Votruba, Ph.D.
[email protected]
(301) 827-3521
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Provision of signed and dated informed consent form.
Agreement to adhere to Lifestyle Considerations throughout study duration.
Males and females; Age \>= 18years
Healthy, as determined by medical history, physical examination, and laboratory tests.

Exclusion

Current use of medications, dietary supplements, or alternative therapies known to alter energy metabolism.
Fasting plasma glucose \>= 126 mg/dL
Type I or Type II Diabetes Mellitus by self-report.
Hematologic disorders including significant anemia (male hemoglobin \< 13.0 g/dL or female hemoglobin \< 11.0 g/dL)
Current pregnancy, pregnancy within the past 6 months or currently lactating
History or self-report of gastrointestinal disease, including inflammatory bowel diseases (e.g. Chron s disease and ulcerative colitis), malabsorption syndromes (e.g. celiac disease), gastric ulcer (active) which may alter metabolism or absorption of study food by self-report
Evidence of alcohol abuse as defined by an 8-point score on the Alcohol consumption screening AUDIT questionnaire in adults.
Participants who report taking large doses of acetaminophen (\> 3 grams daily) who cannot stop acetaminophen 24 hours prior to and following the meal tests will be excluded from the study.
Inability to consume provided food based on a food allergy or intolerance.

What this trial measures

  • To determine whether an adjusted energy dose MMTTor a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs.Baseline, Visit 3/4

    Glucose AUC associated with MMTT conditions (fixed vs. adjusted).