Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study

This study, called the EFFECT Study, is looking at how certain foods might affect thinking skills in adults who feel their memory or thinking isn't as sharp as it used to be. You could be eligible if you are between 40 and 75 years old, have a BMI (Body Mass Index) of 30 or higher, and your HbA1C (a blood test for blood sugar) is less than 6.5%. Participants will either eat 56 grams of walnuts or 68 grams of a dairy-free white chocolate bar each day for one week. Researchers will measure your cognitive function (thinking ability) at the beginning and after five weeks to see if these foods make a difference. The study aims to understand how dietary fats impact thinking and the connection between the gut and brain.

Study design: This is a randomized crossover study, meaning participants will try both interventions at different times. It plans to enroll 88 participants.
What's involved: You would consume one study snack daily for one week. Your cognitive function will be measured at Week 0 and Week 5.
Compensation: Not stated in the trial record.
Follow-up: Your cognitive function will be measured at Week 0 and Week 5, suggesting a follow-up period of at least five weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study

Recruiting

Not specifiedAll Ages

Updated 2026-08-26T02:16:08.402952+00:00 on ClinicalTrials.gov

Conditions

Cognitive Decline

Cognitive Impairment

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Subjective cognitive impairment

BMI ≥30 kg/m2

HbA1C \<6.5%

Exclusion

Diagnosis og cognitive impairment or dementia

Montreal Cognitive Assessment (MoCA) score of \<26

Current or previous diagnosis of Diabetes or use of diabetes medications

Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer

Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods

Hyperthyroidism diagnosis

Food Allergy or intolerances

Any dietary restriction where consumption of the study foods, study meals/snack or meal challenge or any ingredient would be contraindicated

Use of some oil supplements in the past 4 weeks prior to enrolling

Pregnancy and lactation

Inability to access veins for venipuncture

Antibiotic use in the past month

Psychostimulant or nootropic medication use

Current use of supplements or medications for weight loss or following a weight loss program

Severe or uncontrolled autoimmune diseases

Current or previous diagnosis of severe kidney failure, liver cirrhosis and some pulmonary diseases

Heart disease events (including stroke or heart attack) within last 3 months prior to enrollment

Alcohol or drug abuse

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