Back to search results

Weekly Isotretinoin vs. Tetracycline for Moderate Acne

This study is looking for people aged 12 and older with moderate acne (Acne Vulgaris) to compare two treatments: weekly isotretinoin and daily tetracycline. Isotretinoin is a vitamin A-based medication, and tetracycline is an antibiotic. The goal is to see if weekly isotretinoin is as effective as, or better than, the standard daily tetracycline, with fewer side effects. Researchers will measure how well the treatments work using a Comprehensive Acne Severity Scale after 10 months. You cannot join if you've recently taken isotretinoin or are currently on certain long-term antibiotics.

Study design
This is an interventional study planning to enroll 50 participants. It compares two different drug treatments for moderate acne.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, acne severity, will be measured at 10 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06225570

Weekly Isotretinoin vs Tetracycline for Moderate Acne

Recruiting
EARLY_PHASE1Ages 12+InterventionalTreatment
Medical University of South Carolina
~50 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:IsotretinoinTetracycline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Efficacy using Comprehensive Acne Severity Scale
Measured over 10 months

Conditions

Acne Vulgaris

Explore related trials

Acne

Where it's being run

1 sites across 1 states
South Carolina1

Study leadership

  • Alex Richmond, MD, MSCR · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Kathryn Keller, BS
[email protected]
8646301689
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Exclusion

Patients who are at baseline on long-term Tetracycline antibiotics, long-term Trimethoprim-Sulfamethoxazole, or on Spironolactone for any reason
Patients who have taken Isotretinoin in the past 6 months
Patients with hypersensitivity to Isotretinoin or to any of its components
Females who are pregnant, likely to become pregnant, or will be breast-feeding during the study period
Patients with a history of major depression, mania, or psychosis with an active episode during the past year including current psychotic symptoms and/or current suicidal ideation
Adult patients with cognitive impairment
Patients with baseline kidney or liver disease
Patients with baseline hypertriglyceridemia
Patients with history of or current pseudotumor cerebri
Patients with any clinically significant unstable medical condition which could pose a risk to the safety of the patient
Inability or unwillingness of subject or legal guardian/representative to give informed consent

What this trial measures

  • Efficacy using Comprehensive Acne Severity Scale10 months

    Determine the efficacy of weekly isotretinoin therapy for the treatment of moderate acne vulgaris compared to the current SOC therapy, systemic tetracyclines.