Comparing Ticagrelor and Clopidogrel for Coronary Artery Disease

This study is comparing two anti-clotting medications, ticagrelor (60mg twice daily) and clopidogrel (75mg daily), in patients with stable coronary artery disease (CAD) who are having an elective procedure to open blocked heart arteries (percutaneous coronary intervention or PCI). All participants will also take aspirin (81mg daily). We want to see if ticagrelor works better than clopidogrel at preventing blood clots, which is measured by a test called P2Y12 reaction units (PRU) after about 30 days. You might be able to join if you are 18 or older, have stable CAD, and have a specific score (ABCD-GENE score of 10 or higher) that indicates a higher risk for clotting problems. The study is currently recruiting about 50 participants, but its overall status is unclear.

Study design
This is an interventional study comparing two different drug treatments. It plans to enroll about 50 participants.
What's involved
Participants will receive either ticagrelor or clopidogrel for about 30 days, along with aspirin. The primary measurement is taken at 30 days.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at 30 days after starting the study medication.

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NCT06228456

Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention

Recruiting
PHASE4Ages 18+InterventionalTreatment
University of Florida
~50 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:Ticagrelor 60mgClopidogrel

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
P2Y12 reaction units (PRU)
Measured over 30 days
Coronary Artery Disease
1 sites across 1 states
Florida1
  • Francesco Franchi, MD · PRINCIPAL_INVESTIGATOR · Univesrsity of Florida

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  • P2Y12 reaction units (PRU)30 days

    The primary endpoint will be platelet reactivity measured by VerifyNow PRU