Multimodal Musical Stimulation for Healthy Neurocognitive Aging

This study is looking at how multimodal musical stimulation might affect memory in older adults. It's a Stage I randomized, sham-controlled trial, meaning some participants will receive the active stimulation (Gamma or Synchrony devices) and others a control. The Gamma device adds a specific flicker (30-60 Hz) to visual stimulation, while the Synchrony device makes lights pulse and change color with the music's beat. Researchers will measure brain activity (EEG) after 8 weeks to see if these musical stimulations improve working memory. You can join if you are between 18 and 95 years old, have normal vision and no more than mild hearing loss, and no recent neurological or psychiatric conditions. The study aims to understand how brain rhythms affect thinking and could lead to new ways to help with age-related memory changes. The current recruitment status is unclear.

Study design
This is a Stage I randomized, sham-controlled trial with a planned enrollment of 100 participants, including both older and younger adults.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Brain activity (EEG) will be measured at 8 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06229093

Multimodal Musical Stimulation for Healthy Neurocognitive Aging

Recruiting
NAAges 18–95InterventionalBasic science
Northeastern University
~100 participants
Updated 2025-07-10 on ClinicalTrials.gov
What's tested:GammaSynchrony

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
EEG
Measured over 8 weeks
Aging

NCT06229093

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Northeastern University

    Boston, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Psyche Loui, PhD · PRINCIPAL_INVESTIGATOR · Northeastern University

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Eligibility criteria

Inclusion

normal or corrected-to-normal vision
no more than mild hearing loss
no recent history of neurological or psychiatric disorders, including mood disorders or use of medications that may affect cognition or responsiveness to music.

Exclusion

moderate or severe hearing loss (40+ dB)
visual impairment (including color blindness) that cannot be corrected with glasses or contacts
recently changed dosage of cholinesterase inhibitors or psychotropic medication
recent history of psychotic or schizophrenic episodes
major neurologic diagnosis or other condition that might impair cognition or confound assessments (dementia, ADRD; Parkinson's disease, stroke, brain injury, epilepsy, or recent cardiovascular or neurovascular event)
recent history of serious physical trauma or diagnosis of serious chronic health condition requiring medical treatment and monitoring .
  • EEG8 weeks

    Delta, theta, and gamma frequencies