Mango Intake for Immune and Cognitive Benefits in Young Adults
This study is looking at how eating mangos might affect your immune system and thinking abilities (cognition). Participants will be college students aged 18-30. If you join, you would eat 1.5 cups of mangos every day for 12 weeks. Researchers will measure changes in your immune cells (lymphocyte populations), how active they are (lymphocyte activity), and the chemicals they produce (cytokine production) to see if mango consumption has a positive effect. You can't join if you're allergic to mangos, already eat a lot of similar fruits, or take supplements for your brain or immune system. The current status of this study is unclear.
- Study design
- This is an interventional study planning to enroll 54 participants. It's a randomized controlled study, meaning participants will be assigned by chance to either eat mangos or not.
- What's involved
- Participants in the mango group will consume 1.5 cups of mangos per day for 12 weeks. Measurements of immune markers will be taken at the beginning and end of this 12-week period.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints are measured from baseline to 12 weeks, indicating follow-up during this period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Immune and Cognitive Benefits of Mango Intake in Young Adults
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Sujatha Rajaram, PhD · PRINCIPAL_INVESTIGATOR · Loma Linda University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Changes in lymphocyte populationsbaseline to 12 weeks
Immunophenotyping will be performed by flow cytometry to measure the number of T helper, T cytotoxic, Naive and memory cells and B cells
- Changes in Lymphocyte activitybaseline to 12 weeks
The production of lymphocytes will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)
- Changes in cytokine productionbaseline to 12 weeks
The cytokines produced due to lymphocyte activity will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)
- Changes in serum inflammatory cytokine concentrationbaseline to 12 weeks
changes in the concentrations of the inflammatory cytokines will be performed on serum using enzyme linked immunoassay (ELISA) will include hs-CRP, interleukin (IL)-1B, IL-6, TNF a, IL-10, IL-2, IFN-γ, E-selectin,
- changes from baseline in global cognitive composite scorebaseline to 12 weeks
The composite score will be calculated using the scores from the tests listed below. Scores will be calculated with the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test
- Change in serum brain-derived neurotrophic factor (pg/mL)baseline to 12 weeks
changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA