Speech Pattern Evaluation for Alzheimer's Disease Risk

This observational study, called "Speech Pattern Evaluation and Analysis for Knowledge of AD," is looking at how speech patterns might change in people at risk for Alzheimer's disease. Researchers want to see if changes in your speech can be an early sign of thinking and memory problems. You would use an iPad at home to record your speech once a week for 8 weeks, and this would happen each year for three years. The main goals are to see how easy it is to collect speech remotely at home and if it's practical to do so. To join, you must be between 40 and 80 years old and already be part of the Wisconsin Alzheimer's Disease Research Center (W-ADRC) or the Wisconsin Registry for Alzheimer's Prevention (WRAP) studies. You can have normal thinking abilities or mild cognitive impairment (MCI).

Study design
This is an observational study aiming to enroll 165 participants. It is not testing a new medicine but rather observing speech patterns.
What's involved
You would complete speech collection sessions and a survey at home using an iPad once a week for 8 weeks, yearly, for a total of 3 years.
Compensation
Not stated in the trial record.
Follow-up
The study will track usability and feasibility of speech collection for 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06230783

Speech Pattern Evaluation and Analysis for Knowledge of AD

Recruiting
Not specifiedAges 40–80Observational
University of Wisconsin, Madison
~165 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:TalkTracker

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Usability of remote at-home speech collection - objective
Measured over 3 years
+5 more outcomes measured
Wisconsin Alzheimer's Disease Research Center
Wisconsin Registry for Alzheimer's Prevention
1 sites across 1 states
Wisconsin1
  • Kimberly D Mueller, PhD, CCC-SLP · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Must be enrolled in the Wisconsin Alzheimer's Disease Research Center (W-ADRC) Clinical Core or IMPACT studies, or in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
Cognitively unimpaired or have a diagnosis of Mild Cognitive Impairment (MCI)
Ages 40-80 years
Completion of a W-ADRC or WRAP study visit within the past or upcoming 12 months
Have provided W-ADRC or WRAP with blood plasma Alzheimer's Disease

Exclusion

Not actively enrolled in W-ADRC or WRAP
Diagnosis of dementia
Impaired capacity or unwilling to consent
Major neurological conditions
Speech disorders
  • Usability of remote at-home speech collection - objective3 years

    Usability will be measured objectively through the TalkTracker mobile application by obtaining compliance metrics (number of tasks completed, total number of errors, number of help requests).

  • Usability of remote at-home speech collection - objective3 years

    Usability will be measured objectively through the TalkTracker mobile application by obtaining compliance metric of time to completion.

  • Feasibility of remote at-home speech collection3 years

    Feasibility will be measured through numbers of retention, adherence, and accrual.

  • Feasibility of remote at-home speech collection3 years

    Feasibility will be measured through sample characteristics, and identification of productive recruitment methods.

  • Feasibility of remote at-home speech collection3 years

    Feasibility will be measured through identification of productive recruitment methods.

  • Usability of remote at-home speech collection - subjective3 years

    Subjective measurement usability will be assessed through the System Usability Scale (SUS) given to participants after each 8-week completion period. The SUS is a 7 item questionnaire, with a range of 1 to 5 (1 = strongly disagree, 5 = strongly agree). Higher scores on questions 1, 3, 5 and 7 indicate lower usability. Higher scores on questions 2, 4 and 6 indicate higher usability.