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NCT06230887

Implementation of Innovative Treatment for Moral Injury Syndrome: A Hybrid Type 2 Study

Enrolling by Invitation
NAAges 18+InterventionalHealth services
VA Office of Research and Development
~200 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Building Spiritual StrengthPresent Centered Group Therapy

At a glance

Recruiting sites
0 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Moral Injury and Distress Scale
Measured over 8 weeks (end of treatment) and 20 weeks (long-term follow-up)
+2 more outcomes measured

Conditions

Moral Injury Syndrome

Explore related trials

Moral Injury SyndromePost-Traumatic Stress Disorder

Where it's being run

5 sites across 5 states
Arkansas1
Georgia1
Maine1
Minnesota1
Texas1

Study leadership

  • Jeffrey M Pyne, MD · PRINCIPAL_INVESTIGATOR · Central Arkansas Veterans Healthcare System , Little Rock, AR

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

(a) validation of any of the first three items on the Moral Injury and Distress Scale, which is consistent with probable MIS
(b) willingness to be randomized to either treatment condition
(c) stability on mental health medications for at least 8 weeks
(d) age of 18 years or older

Exclusion

(a) insufficient capacity to consent
(b) active psychosis or substance use at levels that would interfere with treatment, assessed via chart review, the Alcohol Use Disorders Identification Test - Concise (AUDIT-C) score, and the Mini International Neuropsychiatric Interview (MINI)
(c) currently involved in evidence-based psychotherapy for MIS, or evidence-based psychotherapy for PTSD, assessed via chart review and intake interview
(d) managing any severe psychopathology that, in the opinion of the investigative team, requires immediate clinical attention, such as imminent suicide risk, assessed via the MINI and supplemental homicide risk questions.

What this trial measures

  • Change in Moral Injury and Distress Scale8 weeks (end of treatment) and 20 weeks (long-term follow-up)

    Full Scale Name: Moral Injury and Distress Scale Score Range: 0-90, with higher scores indicating more symptoms.

  • Change in Moral Injury Outcomes Scale8 weeks (end of treatment) and 20 weeks (long-term follow-up)

    Full Scale Name: Moral Injury and Distress Scale Score Range: 0-56, with higher scores indicating more symptoms.

  • Change in Religious and Spiritual Struggles Scale8 weeks (end of treatment) and 20 weeks (long-term follow-up)

    Full Scale Name: Religions and Spiritual Struggles Scale Score Range: 0=4 with higher scores indicating more symptoms