Mindfulness-assisted Psilocybin Therapy for Mental Health
This study is looking at whether adding mindfulness training to psilocybin treatment can improve mental health. Researchers want to see if mindfulness training enhances the effects of psilocybin (a psychoactive compound found in certain mushrooms) in healthy adults. You might be eligible if you are 25 or older, haven't had formal mindfulness training, and haven't used classic psychedelics before. The study will measure how many people stay in the study and changes in stress symptoms after 8 weeks. The current recruitment status is unclear, but 40 people are planned to join.
- Study design
- This is an interventional study where 40 participants will be randomly assigned to one of two groups: psilocybin with mindfulness training, or psilocybin alone.
- What's involved
- You will complete an initial eligibility session, then baseline and post-treatment assessments including questionnaires, cognitive tests, and an EEG (a measure of brain activity). You will also complete two follow-up surveys at 8 weeks and 1 year after treatment.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 1 year after the post-treatment assessment, with surveys at 8 weeks and 1 year.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mindfulness-Assisted Psychedelic Therapy
At a glance
Conditions
NCT06233344
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Univeristy of Southern California Brain and Creativity Institute
Los Angeles, Californiastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Baruch R Cahn, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Southern California
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Retention at 8-week follow-up8-week follow-up
The primary feasibility outcome will be participant retention (percent of eligible enrolled participants who complete the 8-week follow-up session)
- Change in stress symptoms8-week follow-up
The primary efficacy outcome will be the Short Perceived Stress Scale. This 10-item scale asks participants to rate how frequently they felt certain ways (such as nervous, "stressed", or unable to control important things in their lives) on a scale from 0 (Never) to 4 (Very often). Total scores range from 0-40; higher scores indicate higher levels of perceived stress.