This study at Northwestern University is for people with knee osteoarthritis (OA) pain. It aims to understand why some people respond to certain pain medicines and others don't. You could be eligible if you are over 40, have knee OA confirmed by X-ray, and experience knee pain most days, with an average pain score of 4 or higher out of 10. The study will last about 20 weeks. You will be randomly assigned to receive either duloxetine, celecoxib, or a placebo (an inactive pill). Researchers will measure how many people have at least a 30% reduction in their pain after 6 and 16 weeks of treatment. The study is currently unclear about its recruitment status and plans to enroll 180 participants.

Study design

This is an interventional study where 180 participants will be randomly assigned to one of three treatment groups: duloxetine, celecoxib, or placebo. The study design involves a repeat-treatment approach.

What's involved

You would participate for about 20 weeks, have a knee X-ray, optional brain and knee MRIs, blood draws, pain sensitivity tests, and complete questionnaires.

Compensation

Not stated in the trial record.

Follow-up

Pain response will be measured at the end of the first treatment period (week 6) and the second treatment period (week 16).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.