This study is looking into how minocycline hydrochloride, an antibiotic, might help people with high blood pressure that hasn't responded to other treatments (resistant hypertension). Researchers want to see if minocycline hydrochloride 100 mg taken twice daily can lower blood pressure. They also want to understand if any blood pressure changes are linked to changes in your gut bacteria (gut microbiota), gut inflammation, or other body processes. You could be eligible if you are 18 to 100 years old and have uncontrolled resistant hypertension, even while taking three or more blood pressure medications. The study aims to enroll 120 participants and will measure your 24-hour systolic blood pressure, gut microbiome, and gut inflammation after 3 months to see if the treatment is successful. The current recruitment status is unclear.

Study design

This is an interventional study where 120 participants will be randomly assigned to receive either minocycline hydrochloride or a placebo. Neither you nor the researchers will know which treatment you are receiving (blinded).

What's involved

You would participate for 3 months, with 3 visits: screening, randomization, and a 3-month follow-up. These visits include medical history, questionnaires, blood and urine/saliva tests, stool samples, and blood pressure measurements. Some participants will also have brain imaging.

Compensation

Not stated in the trial record.

Follow-up

Your blood pressure, gut microbiome, and gut inflammation will be measured at 3 months after starting treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.