Naloxone for Opioid-Associated Out-of-Hospital Cardiac Arrest
This study is investigating if naloxone (a medication that reverses opioid effects) can help people who have a cardiac arrest (when the heart stops beating) outside of a hospital due to an opioid overdose. Participants will receive either naloxone 2mg or a saline placebo (an inactive substance) through an IV or IO (into the bone) route, shortly after receiving epinephrine. The main goal is to see if naloxone improves survival until hospital discharge, which is typically up to 5 days. You might be eligible if you are an adult (18 years or older) experiencing cardiac arrest outside the hospital, have already received initial resuscitation efforts including epinephrine, and are suspected of having an opioid-related cardiac arrest. The current recruitment status is unclear.
- Study design
- This is a randomized, controlled trial with 98 planned participants. It compares naloxone to a placebo.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed until hospital discharge, which is an average of up to 5 days.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Ralph Wang, MD, MAS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
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Do you actually qualify for this trial?
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Exclusion
What this trial measures
- Survival to hospital dischargeThrough hospital discharge, an average of up to 5 days
Survival to hospital discharge is defined as patient is discharged from the hospital acute care unit alive regardless of neurological status, outcome or destination.