Maximizing Lymph Node Dissection for Lung Cancer

This study is looking at how to best remove lymph nodes during surgery for lung cancer. Doctors want to see if a standardized way of removing lymph nodes from the lung tissue after it's taken out can help find more lymph nodes. Finding more lymph nodes can help doctors better understand the cancer's stage and decide if more treatments are needed. You might be able to join if you have a lung nodule or mass, are at least 18 years old, and are having a lobectomy (surgery to remove a lobe of your lung) for a peripheral (outer) lung nodule without any signs of the cancer having spread. The study will measure the number of lymph nodes found and how often the cancer's stage is changed based on these findings, both measured at 2 weeks after surgery. The current status of this study is unclear.

Study design
This interventional study plans to enroll 160 participants. It compares a standardized lymph node dissection technique to a control group.
What's involved
You would undergo a lobectomy, and your removed lung tissue would have lymph nodes dissected either by your surgeon or a pathology team member.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes, such as the number of lymph nodes sampled and nodal upstage rate, are measured at 2 weeks.

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NCT06252129

Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

Recruiting
NAAges 18+InterventionalDiagnostic
Brigham and Women's Hospital
~160 participants
Updated 2026-03-05 on ClinicalTrials.gov
What's tested:Subjects undergoing a lung specimen lymph node dissectionControl group

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of lymph nodes sampled
Measured over 2 weeks
+1 more outcome measured
Lung Cancer
Lymph Node Metastasis
Pathologic Processes
1 sites across 1 states
Massachusetts1

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  • Number of lymph nodes sampled2 weeks

    To compare the number of stations and lymph nodes sampled when adopting a standardized technique compared to the conventional (prior) technique.

  • Nodal upstage rate2 weeks

    Determine the number of cases upstaged to N1 with the intrapulmonary lymph node dissection compared to the conventional technique.