LIVER-R: Real-World Study of Durvalumab-Based Treatments for Hepatobiliary Cancers

This study, called LIVER-R, is observing how durvalumab-based treatments work for people with hepatobiliary cancers (cancers of the liver, gallbladder, or bile ducts) in real-world settings. Researchers are collecting information on patients who are already receiving durvalumab-based regimens, such as STRIDE or durvalumab combined with chemotherapy (like GemCis). The study aims to understand how long patients live after starting these treatments. You may be able to join if you are an adult (18 years or older) with a confirmed hepatobiliary cancer that your doctor has decided to treat with a durvalumab-based regimen. The study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning researchers will collect information from your routine medical care. It aims to include about 4490 participants across many countries.
What's involved
Data will be collected during your routine doctor visits and from your medical records. This will happen at enrollment and at 6-month intervals.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for up to 2 years if you have advanced biliary tract cancer, or up to 3 years if you have unresectable hepatocellular carcinoma.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06252753

Observational Study Protocol: LIVER-R

Recruiting
Not specifiedAges 18+Observational
AstraZeneca
~4,000 participants
Updated 2026-09-08 on ClinicalTrials.gov
What's tested:Durvalumab-based combination therapies in observational study settingNon Durvalumab-based therapies in observational study settingDurvalumab-based combination therapies in observational study settings

At a glance

Recruiting sites
159 of 160 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Real-world overall survival (rwOS) in all participants
Measured over rwOS will be assessed as OS rates at 6, 12, 18, 24, and 36 months, as applicable per the type of hepatobiliary cancer; median OS for a minimum follow-up of 2 years.
Hepatobiliary Cancers

NCT06252753

Where you'd take part

This study runs at 160 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Research Site

    Birmingham, Alabamano site contact published

    Recruiting

  • Research Site

    Mobile, Alabamano site contact published

    Recruiting

  • Research Site

    Phoenix, Arizonano site contact published

    Recruiting

  • Research Site

    Coronado, Californiano site contact published

    Recruiting

  • Research Site

    Los Angeles, Californiano site contact published

    Recruiting

  • Research Site

    Walnut Creek, Californiano site contact published

    Recruiting

  • Research Site

    Clermont, Floridano site contact published

    Recruiting

  • Research Site

    Gainesville, Floridano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

AstraZeneca Clinical Study Information Center
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

  • Real-world overall survival (rwOS) in all participantsrwOS will be assessed as OS rates at 6, 12, 18, 24, and 36 months, as applicable per the type of hepatobiliary cancer; median OS for a minimum follow-up of 2 years.

    rwOS will be calculated as the time from the index date to date of death, by any cause.