Assessing Coronary Blood Flow with Carbon Dioxide in Coronary Artery Disease
This pilot study is looking at a new way to measure blood flow in the heart for people with coronary artery disease (CAD). You would breathe different combinations of carbon dioxide and oxygen using a device called RespirAct. Researchers want to see if this method is safe, well-tolerated, and technically possible. To join, you must be an adult over 18 with suspected or known CAD, and your previous heart tests (SPECT/PET or FFR) need to show at least mild to moderate reduced blood flow to your heart. The study will measure changes in your heart's blood flow using MRI scans. The current recruitment status is unclear, and the study aims to enroll 30 participants.
- Study design
- This is a pilot study involving 30 participants to test a new method. The phase of the study is not specified.
- What's involved
- You would breathe various combinations of carbon dioxide and oxygen. Your heart's blood flow would be assessed using MRI scans.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary measurements are taken at 3 hours after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Ratio of Maximum Signal Intensity (MSI) by BOLD MRI3 hours
Maximum Signal Intensity (MSI) quantification will be measured through myocardial perfusion by blood oxygen level dependent (BOLD) MRI. The ratio of MSI in hypercarbia vs normocarbia will be evaluated in the 17-segment LV model.
- Ratio of Maximum Signal Intensity (MSI) by FFP MRI3 hours
Maximum Signal Intensity (MSI) quantification will be measured through myocardial perfusion by first pass perfusion (FFP) MRI. The ratio of MSI in hypercarbia vs normocarbia will be evaluated in the 17-segment LV model.