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Observational Study on Pregnancy and Recurrent Cervical Artery Dissection

This study is looking at whether pregnancy increases the risk of having another cervical artery dissection (CeAD), which is a tear in an artery in the neck that can lead to stroke. Researchers will review long-term medical records from women who have already experienced a CeAD. They want to see if women who became pregnant after their first CeAD had a higher chance of a second CeAD, a stroke, or death. The study will also explore if the type of delivery affects this risk and if women decided against future pregnancies due to their initial CeAD. This study aims to understand these risks better, as previous studies were often small or lacked long-term information.

Study design
This is an observational study that will gather information from medical records of about 1000 women. It is a case-control study, meaning it compares groups of people with and without a certain outcome.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will look at outcomes from the date of your first CeAD until your latest follow-up, up to 35 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06258109

Risk of Recurrent CeAD After Pregnancy

Recruiting
Not specifiedAges 18+Observational
University Hospital, Basel, Switzerland
~1,000 participants
Updated 2024-12-13 on ClinicalTrials.gov

At a glance

Recruiting sites
12 of 12 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants with composite outcome measure - recurrent CeAD, ischemic stroke, hemorrhagic stroke and/or death
Measured over From date of first CeAD until date of latest follow-up assessed up to 35 years

Conditions

Cervical Artery Dissection
Pregnancy Complications

Explore related trials

Cervical artery dissectionHemorrhagic StrokeIschemic StrokePregnancy Complication

Where it's being run

12 sites across 10 states
Germany2
Switzerland2
Utah1
Virginia1
Argentina1
Tyrol1
Finland1
Israel1

Study leadership

  • Stefan T Engelter, MD · PRINCIPAL_INVESTIGATOR · University Hospital, Basel, Switzerland

Who to contact

Stefan T Engelter, MD
[email protected]
+41 61 326 41 05
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Eligibility criteria

Inclusion

female
prior symptomatic cervical artery dissection (= index CeAD)
at least one long-term follow-up visit (at least 6 months after the initial event)
with information available on outcome events:
recurrent dissection
ischemic stroke
hemorrhagic stroke
functional outcome assessed by mRS score
with data on pregnancy after the initial event
at least 18 years old at the initial event

Exclusion

Male patients
Age \<18 years
No long-term follow-up available or long-term follow-up \< 6 months after initial event
No data on pregnancy after initial event available

What this trial measures

  • Number of participants with composite outcome measure - recurrent CeAD, ischemic stroke, hemorrhagic stroke and/or deathFrom date of first CeAD until date of latest follow-up assessed up to 35 years

    The composite outcome measure includes the following outcome measures during the follow-up: (i) occurence of recurrent cervical artery dissection (CeAD), (ii) occurrence of any ischemic stroke, (iii) occurrence of any hemorrhagic stroke, (iv) death.