Magnesium and Riboflavin for Post-Concussion Headache

This study is looking into whether taking magnesium and riboflavin supplements can help reduce how bad and how long headaches last after a concussion. You might be able to join if you are between 18 and 40 years old, have been diagnosed with a concussion at the University of Virginia Student Health and Wellness Center or Emergency Department less than 3 days ago, and can swallow capsules. We are hoping to see a decrease in headache intensity and duration after 14 days. The current recruitment status is unclear, but the study plans to enroll 108 people.

Study design
This is an interventional study where participants will be randomly assigned to receive either magnesium and riboflavin capsules or inactive (placebo) capsules. It plans to enroll 108 participants.
What's involved
You would take capsules once a day for 14 days, complete a short daily diary for 14 days, and have 3 follow-up visits either by phone or in person.
Compensation
Not stated in the trial record.
Follow-up
Headache intensity and duration will be measured at 14 days.

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NCT06260072

Magnesium and Riboflavin Treatment for Post-Concussion Headache

Recruiting
PHASE2Ages 18–40InterventionalTreatment
University of Virginia
~108 participants
Updated 2025-03-27 on ClinicalTrials.gov
What's tested:magnesium and riboflavin supplement

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Headache Intensity and Duration
Measured over 14 days
Concussion, Intermediate
1 sites across 1 states
Virginia1
  • Stephanie Hartman, MD · PRINCIPAL_INVESTIGATOR · UVA Student Health and Wellness

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Seen at University of Virginia Student Health and Wellness Center or Emergency Department for Initial Visit for Concussion;
Less than 3 days have elapsed since their injury;
Able to swallow capsules

Exclusion

Concussion complicated by cranial bleed, skull fracture, additional severe injury;
Kidney disfunction or failure;
Significant gastro-intestinal dysfunction;
Varsity Athlete;
Two or more previous concussions;
Women who are pregnant or breast feeding;
Taking tetracycline, fluoroquinolone, iron digoxin, chlorpromazine or penicillamine
  • Headache Intensity and Duration14 days

    t-test of mean differences between the groups